Glucocorticoids Ameliorate Antigen-Induced Bronchial Smooth Muscle Hyperresponsiveness by Inhibiting Upregulation of RhoA in Rats

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概要

• 論文の詳細を見る

• To determine the mechanism(s) of the inhibitory effect of glucocorticoids on airway hyperresponsiveness in allergic bronchial asthma, the effects of systemic treatment with glucocorticoids on bronchial smooth muscle hyperresponsiveness and RhoA upregulation were investigated in rats with allergic bronchial asthma. Rats were sensitized and repeatedly challenged with 2,4-dinitrophenylated Ascaris suum antigen. Animals were also treated with prednisolone or beclomethasone (each 10 mg/kg, i.p.) once a day during the antigen inhalation period. Repeated antigen inhalation caused a marked bronchial smooth muscle hyperresponsiveness to acetylcholine with an upregulation of RhoA. Augmented acetylcholine-induced activation of RhoA and phosphorylation of myosin light chain were observed in bronchial smooth muscles of the antigen-exposed animals. Systemic treatment with either glucocorticoid used inhibited the bronchial smooth muscle hypercontraction until the level of the sensitized control rats that received saline inhalation instead of antigen challenge. Interestingly, both glucocorticoids also inhibited the upregulation of RhoA and augmented acetylcholine-induced activation of RhoA and phosphorylation of myosin light chain. In conclusion, glucocorticoids ameliorated the augmented bronchial smooth muscle contraction by inhibiting upregulation of RhoA. These effects of glucocorticoids may account for, in part, their beneficial effects in the treatment of asthma.

• 社団法人 日本薬理学会の論文
• 2008-04-20

著者

• CHIBA Yoshihiko

  Department of Pharmacology, School of Pharmacy, Hoshi University

• MISAWA Miwa

  Department of Pharmacology, School of Pharmacy, Hoshi University

• Goto Kumiko

  Department of Pharmacology, School of Pharmacy, Hoshi University, Japan

• SAKAI Hiroyasu

  Department of Internal Medicine, Gifu University Graduate School of Medicine

• 千葉 喜彦

  山口大学理学部時間生物学研究室

• Chiba Yoshihiko

  Dep. Of Pharmacology School Of Pharmacy Hoshi Univ.

• HIRAHARA Mayu

  Department of Pharmacology, School of Pharmacy, Hoshi University

• Chiba Yoshihiko

  Department Of Pharmacology School Of Pharmacy Hoshi University

• Misawa Miwa

  Department Of Pharmacology School Of Pharmacy Hoshi University

• Misawa M

  Hoshi Univ. Tokyo Jpn

• Misawa Miwa

  Department Of Applied Pharmacology Hoshi University

• Goto Kumiko

  Department Of Applied Physics Faculty Of Engineering Hokkaido University

• Hirahara Mayu

  Department Of Pharmacology School Of Pharmacy Hoshi University

• Sakai Hiroyasu

  Department Of Pharmacology School Of Pharmacy Hoshi University

• Sakai H

  Department Of Pharmaceutical Physiology Graduate School Of Medicine And Pharmaceutical Sciences Univ

• Goto Kumiko

  Department Of Pharmacology School Of Pharmacy Hoshi University

• Sugitani Hideki

  Department Of Clinical Chemistry Hoshi University School Of Pharmacy And Pharmaceutical Sciences

• Chiba Yoshihiko

  Department Of Biology School Of Pharmacy Hoshi University

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