Inhibition of antigen-induced bronchial smooth muscle hyperresponsiveness by lovastatin in mice
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概要
- 論文の詳細を見る
Statins have been proposed as a novel treatment of respiratory diseases. To determine the beneficial effects of statins on the airway hyperresponsiveness, a characteristic feature of allergic bronchial asthma, the effect of systemic treatment with lovastatin on antigen-induced bronchial smooth muscle hyperresponsiveness was investigated in mice. Male BALB/c mice were sensitized and repeatedly challenged with ovalbumin antigen. Animals were also treated with lovastatin (4mg/kg/day, i.p.) once a day prior to and during the antigen inhalation period. The bronchial smooth muscle responsiveness to acetylcholine, but not to high K^+-depolarization, was markedly and significantly augmented in the repeatedly antigen challenged mice. The bronchial smooth muscle hyperresponsiveness to acetylcholine induced by antigen exposure was significantly attenuated by the systemic treatment with lovastatin. Thus, lovastatin might have therapeutic potential to ameliorate airway hyperresponsiveness in allergic bronchial asthma.
- 日本平滑筋学会の論文
著者
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MISAWA Miwa
Department of Pharmacology, School of Pharmacy, Hoshi University
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Chiba Yoshihiko
Dep. Of Pharmacology School Of Pharmacy Hoshi Univ.
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Sato Shunsuke
Department Of Pharmacology School Of Pharmacy Hoshi University
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Chiba Yoshihiko
Department Of Pharmacology School Of Pharmacy Hoshi University
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Misawa Miwa
Department Of Pharmacology School Of Pharmacy Hoshi University
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Misawa M
Hoshi Univ. Tokyo Jpn
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Misawa Miwa
Department Of Applied Pharmacology Hoshi University
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Sato Shunsuke
Department Of Medical Engineering Aino University
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Chiba Yoshihiko
Department Of Biology School Of Pharmacy Hoshi University
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SATO Shunsuke
Department of Cardiac Surgery, National Cerebral and Cardiovascular Center
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