Upregulation of rhoA mRNA in Bronchial Smooth Muscle of Antigen-induced Airway Hyperresponsive Rats
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概要
- 論文の詳細を見る
It has recently been suggested that RhoA plays an important role in the enhancement of Ca^<2+> sensitization observed in smooth muscle contraction. In the present study, the expression of rhoA mRNA in the bronchial smooth muscle of antigen-induced airway hyperresponsive rats was compared with that of control animals. Reverse transcription- polymerase chain reaction experiments using total RNA from these tissue specimens and the specific primers revealed rhoA mRNA to be expressed in bronchial smooth muscle of the rat. The rhoA mRNA expression in bronchial smooth muscle of the hyperresponsive rats was significantly increased in comparison to that of control animals. It is thus possible that upregulation of RhoA protein might be involved in the mechanism underlying the increased contractility of the bronchial smooth muscle which occurs with airway hyperresponsiveness.
- 日本平滑筋学会の論文
著者
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CHIBA Yoshihiko
Department of Pharmacology, School of Pharmacy, Hoshi University
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MISAWA Miwa
Department of Pharmacology, School of Pharmacy, Hoshi University
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Sakamoto Yoshimitsu
星薬科大学 臨床化学
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SAKAI Hiroyasu
Department of Internal Medicine, Gifu University Graduate School of Medicine
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千葉 喜彦
山口大学理学部時間生物学研究室
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Wachi Hiroshi
Faculty Of Technokogy Tokyo University Of Agriculture And Technology
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Wachi Hiroshi
Department Of Clinical Chemistry Hoshi University School Of Pharmacy And Pharmaceutical Sciences
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Wachi Hiroshi
Department Of Clinical Chemistry Hoshi College Of Pharmacy
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Wachi Hiroshi
星薬科大学 臨床化学教室
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SEYAMA Yoshiyuki
Department of Clinical Chemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences
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SUGITANI Hideki
Department of Clinical Chemistry, School of Pharmacy, Hoshi University
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Chiba Yoshihiko
Department Of Pharmacology School Of Pharmacy Hoshi University
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Misawa Miwa
Department Of Pharmacology School Of Pharmacy Hoshi University
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Misawa Miwa
Department Of Applied Pharmacology Hoshi University
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Seyama Yoshiyuki
Department Of Clinical Chemistry Hoshi College Of Pharmacy
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Sakai Hiroyasu
Department Of Pharmacology School Of Pharmacy Hoshi University
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Sakai H
Department Of Pharmaceutical Physiology Graduate School Of Medicine And Pharmaceutical Sciences Univ
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Sugitani Hideki
Department Of Clinical Chemistry Hoshi University School Of Pharmacy And Pharmaceutical Sciences
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Chiba Yoshihiko
Department Of Biology School Of Pharmacy Hoshi University
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SEYAMA YOSHIYUKI
Department of Biochemistry, Tokyo College of Pharmacy
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