Increased expression of Gαq protein in bronchial smooth muscle of mice with allergic bronchial asthma
スポンサーリンク
概要
- 論文の詳細を見る
In the present study, the change in Gq protein level in bronchial smooth muscle of mice with antigen-induced airway hyperresponsiveness (AHR) was determined. BALB/c mice were actively sensitized and repeatedly challenged with ovalbumin antigen to induce bronchial smooth muscle hyperresponsiveness. The contraction induced by 10 μM AlF_4^- (generated by 10μM AlCl_3 plus 10 mM NaF) of bronchial smooth muscles isolated from the antigen-challenged mice was significantly augmented as compared with that from the control animals. The Gαq protein level determined by immunoblotting was also significantly increased in bronchial smooth muscles of the antigen-challenged group. Thus, an upregulation of Gαq protein may be involved in the pathogenesis of bronchial smooth muscle hyperresponsiveness, one of the causes of AHR in asthmatics.
- 日本平滑筋学会の論文
著者
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CHIBA Yoshihiko
Department of Pharmacology, School of Pharmacy, Hoshi University
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MISAWA Miwa
Department of Pharmacology, School of Pharmacy, Hoshi University
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SAKAI Hiroyasu
Department of Internal Medicine, Gifu University Graduate School of Medicine
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千葉 喜彦
山口大学理学部時間生物学研究室
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Chiba Yoshihiko
Dep. Of Pharmacology School Of Pharmacy Hoshi Univ.
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UENO Ayako
Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University
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SHINOZAKI Koji
Department of Pharmacology, School of Pharmacy, Hoshi University
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Chiba Yoshihiko
Department Of Pharmacology School Of Pharmacy Hoshi University
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Ueno Ayako
Department Of Immunochemistry Faculty Of Pharmaceutical Sciences Okayama University
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Ueno Ayako
Department Of Pharmacology School Of Pharmacy Hoshi University
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Misawa Miwa
Department Of Pharmacology School Of Pharmacy Hoshi University
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Misawa M
Hoshi Univ. Tokyo Jpn
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Misawa Miwa
Department Of Applied Pharmacology Hoshi University
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Shinozaki Koji
Department Of Pharmacology School Of Pharmacy Hoshi University
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Shinozaki Koji
Department Of Pediatrics Shinshu University School Of Medicine
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Sakai Hiroyasu
Department Of Pharmacology School Of Pharmacy Hoshi University
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Sakai H
Department Of Pharmaceutical Physiology Graduate School Of Medicine And Pharmaceutical Sciences Univ
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Sugitani Hideki
Department Of Clinical Chemistry Hoshi University School Of Pharmacy And Pharmaceutical Sciences
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Chiba Yoshihiko
Department Of Biology School Of Pharmacy Hoshi University
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