EFFECTS OF NIFEDIPINE ON PHYSICAL DEPENDENCE ON BARBITAL OR DIAZEPAM IN RATS

スポンサーリンク

概要

• 論文の詳細を見る

• The effects of nifedipine on the development of physical dependence on barbital and diazepam in rats were examined using the drug-admixed food method. Rats were chronically treated with either barbital- or barbital in combination with nifedipine-admixed food for 28 days, and with either diazepam- or diazepam in combination with nifedipine-admixed food for 26 days, on schedules of gradually increasing doses of barbital or diazepam. Withdrawal was conducted by substituting normal food for drug-admixed food on the last day of the treatment. Co-administration of nifedipine with barbital potentiated body weight loss and withdrawal scores after the termination of barbital treatment. However, the withdrawal signs after the termination of diazepam treatment were not affected by co-administration of nifedipine with diazepam. These results suggest that nifedipine potentiates the development of physical dependence on barbital but not diazepam. It is known that co-administration of dihydropyridine derivative nitrendipine suppresses the development of physical dependence on ethanol. Basing on the differences in sensitivity of central depressants, barbiturates, benzodiazepines and ethanol, to three types of voltage-dependent Ca^<2+> channels, such as L-, N- and T-types studied so far, the development of physical dependence on central depressants may be modified differently by L-type Ca^<2+> channel blockers, corresponding to respective depressants.

• 日本トキシコロジー学会の論文
• 1995-09-25

著者

• MISAWA Miwa

  Department of Pharmacology, School of Pharmacy, Hoshi University

• SUZUKI Tsutomu

  Department of Applied and Environmental Chemistry, Kitami Institute of Technology

• MIZOGUCHI Hirokazu

  Department of Physiology and Anatomy, Tohoku Pharmaceutical University

• Misawa Miwa

  Department Of Applied Pharmacology Hoshi University

• MOTEGI Hiroshi

  Department of Materials Sceince, Faculty of Science, Horishima University

• MOTEGI Hiroshi

  Faculty of Science,Hiroshima University

• Motegi Hiroshi

  Department Of Materials Science Faculty Of Science Hiroshima University

• Motegi Hiroshi

  Department Of Materials Sceince Faculty Of Science Horishima University:japan Maritime Safety Academ

• Motegi Hiroshi

  Faculty Of Science Hiroshima University

• Motegi Hiroshi

  Department Of Pharmacology School Of Pharmacy Hoshi University

• Suzuki Tsutomu

  Dep. Of Toxicology Hoshi Univ. School Of Pharmacy And Pharmaceutical Sciences Jpn

• AWANO Hideto

  Department of Pharmacology, School of Pharmacy, Hoshi University

• Mizoguchi Hirokazu

  Department Of Anesthesiology Medical College Of Wisconsin

• Awano Hideto

  Department Of Pharmacology School Of Pharmacy Hoshi University

• Suzuki Tsutomu

  Department Of Applied And Environmental Chemistry Kitami Institute Of Technology

関連論文

• Upregulation of interleukin-13 receptor chains in bronchial smooth muscle tissues of mouse experimental asthma
• Identification and Characterization of Rat RhoA Gene Promoter
• Nickel-catalyzed carbonization of wood for coproduction of functional carbon and fluid fuels II : improved fuel quality of oil fraction and increased heating value of gas fraction
• Nickel-catalyzed carbonization of wood for coproduction of functional carbon and fluid fuels I : production of crystallized mesoporous carbon
• Preparation of Crystallized and Mesoporous Carbon by Nickel-catalyzed Carbonization of Wood
• Electromagnetic Shielding Capacity of Wood Char Loaded with Nickel
• Gastric Tube Interposition for Corrosive Esophagitis Associated with Pyloric Stenosis
• Morphine, Oxycodone, and Fentanyl Exhibit Different Analgesic Profiles in Mouse Pain Models
• S2-3 Opiate Psychotoxicity : role of NMDA recepter subunits and protein kinase C(Proceedings of the 27th Annual Meeting)
• Effects of insulin replacement on ejaculatory dysfunction in streptozotocin-induced diabetic rats
• 1SE1020 Genetic code extension and establishment by aminoacyl-tRNA synthetase and tRNA modification enzymes(1SE Recent Advances in Structural Analyses of Funcitonal Mechanisms Based on Dynamics of Biological Reactions,The 48th Annual Meeting of the Biophy
• BEHAVIORAL CHANGES IN MORPHINE-TOLERANT MICE
• STUDIES ON DRUG DEPENDENCE (REPT. 72) BRAIN MORPHINE LEVELS OF DEPENDENT MICE BY DAF (DRUG-ADMIXED FOOD) METHOD
• STUDIES ON DRUG DEPENDENCE (REPT. 52) INDUCTION OF MORPHINE DEPENDENT MICE BY DAF (DRUG-ADMIXED FOOD) METHOD
• Augmentation of Endothelin-1-Induced Phosphorylation of CPI-17 and Myosin Light Chain in Bronchial Smooth Muscle from Airway Hyperresponsive Rats(Pharmacology)
• Generalization of NMDA-Receptor Antagonists to the Discriminative Stimulus Effects of κ-Opioid Receptor Agonists U-50,488H, but Not TRK-820 in Rats
• Lack of μ-Opioid Receptor-Mediated G-Protein Activation in the Spinal Cord of Mice Lacking Exon 1 or Exons 2 and 3 of the MOR-1 Gene
• TRK-820, a Selective к-Opioid Agonist, Produces Potent Antinociception in Cynomolgus Monkeys
• INTERACTION BETWEEN MU AND KAPPA RECEPTORS IN PHARMACOLOGICAL EFFECTS OF TOLERANCE TO AND DEPENDENCE ON SEVERAL OPIOIDS
• SKI-II, an Inhibitor of Sphingosine Kinase, Ameliorates Antigen-Induced Bronchial Smooth Muscle Hyperresponsiveness, but Not Airway Inflammation, in Mice
• Mechanism of Inhibitory Effect of Prednisolone on RhoA Upregulation in Human Bronchial Smooth Muscle Cells
• Possible Involvements of Nuclear Factor-κB and Activator Protein-1 in the Tumor Necrosis Factor-α–Induced Upregulation of Matrix Metalloproteinase-12 in Human Alveolar Epithelial A549 Cell Line
• Tumor Necrosis Factor-α (TNF-α) Induces Upregulation of RhoA via NF-κB Activation in Cultured Human Bronchial Smooth Muscle Cells
• Functional importance of the cytoskeletal protein in acetylcholine-induced contraction of rat bronchial smooth muscle
• Glucocorticoids Ameliorate Antigen-Induced Bronchial Smooth Muscle Hyperresponsiveness by Inhibiting Upregulation of RhoA in Rats
• Increased expression of Gαq protein in bronchial smooth muscle of mice with allergic bronchial asthma
• Probable involvement of epsilon-isoform of protein kinase C in rat bronchial smooth muscle contraction induced by acetylcholine
• Involvements of cysteinyl leukotrienes and nitric oxide in antigen-induced venodilatation of nasal mucosa in sensitized rats in vivo
• Increase in the Expression of Matrix Metalloproteinase-12 in the Airways of Rats with Allergic Bronchial Asthma(Pharmacology)
• Effects of Repeated Antigen Exposure on Endothelin-1-Induced Bronchial Smooth Muscle Contraction and Activation of RhoA in Sensitized Rats
• Involvement of M_3 Muscarinic Receptors in ACh-Induced Increase in Membrane-Associated RhoA of Rat Bronchial Smooth Muscle(Pharmacology)
• Acetylcholine-Induced Translocation of RhoA in Freshly Isolated Single Smooth Muscle Cells of Rat Bronchi
• TNF-α augments the expression of RhoA in the rat bronchus
• Upregulation of rhoA mRNA in Bronchial Smooth Muscle of Antigen-induced Airway Hyperresponsive Rats
• High Electroconductivity of Wood Char Obtained by Iron-catalyzed Carbonization
• Antinociceptive Effect of the Combination of Pentazocine With Morphine in the Tail-Immersion and Scald-Pain Tests in Rats
• Recent Advances in the Search for the μ-Opioidergic System : Endomorphin-induced Motivational Effect : Differential Mechanism of Endomorphin-1 and Endomorphin-2
• Augmented PDBu-mediated contraction of bronchial smooth muscle of mice with antigen-induced airway hyperresponsiveness
• Involvement of multiple PKC isoforms in phorbol 12,13-dibutyrate-induced contraction during high K^+ depolarization in bronchial smooth muscle of mice
• A NEW SCREENING METHOD FOR EVALUATING ANTITUSSIVES IN CONSCIOUS GUINEA PIGS
• HISTAMINE RECEPTORS IN THE BRONCHIAL MUSCULATURE AND VASCULATURE OF THE DOG
• COMPARISON OF PHARMACOLOGICAL PROPERTIES BETWEEN PENTAZOCINE AND HOMOBENZOMORPHAN DERIVATIVES
• DRUG EFFECTS ON ELECTRICAL ACTIVITIES OF THE CANINE TRACHEAL CILIATED CELLS
• DIRECT EFFECTS OF EXPECTORANTS ON THE TRACHEOBRONCHIAL SYSTEM IN VIVO
• EFFECTS OF SOME DRUGS ON THE IMMUNE RESPONSE IN THE RESPIRATORY TRACT
• STUDIES ON THE MECHANISM OF INTERACTION BETWEEN METHAMPHETAMINE AND QUININE IN RATS
• Thoracic Esophagectomy Combined with Pylorus-Preserving Pancreatoduodenectomy in a One-Stage Procedure : Report of a Case
• A Novel Screening System for Self-mRNA Targeting Proteins
• NARCOTIC PHYSICAL DEPENDENCE AND URINARY SEX-DEPENDENT LOW MOLECULAR WEIGHT PROTEINS IN MALE RATS
• Implication of the Descending Dynorphinergic Neuron Projecting to the Spinal Cord in the (+)-Matrine-and (+)-Allomatrine-Induced Antinociceptive Effects(Medicinal Chemistry)
• Combined Effects of Psychostimulants and Morphine on Locomotor Activity in Mice
• Recent Advances in the Search for the μ-Opioidergic System : Differential Mechanism of G-Protein Activation Induced Endogenous μ-Opioid Peptides, Endomorphin and β-Endomorphin
• Modulation of the Discriminative Stimulus Effects of Cocaine and Methamphetamine by the Histaminergic System
• Evaluation of the Histamine H_1-Antagonist-Induced Place Preference in Rats
• Interaction between Discriminative Stimulus Effects of Cocaine and Morphine
• 1P014 Snapshots of tRNA sulfuration via an adenylated intermediate(1. Protein structure and dynamics (I),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
• The Effect of Platelet-Activating Factor on Histamine Release from Guinea Pig Peritoneal Mast Cells
• Design and Simulation of 4Q-Multiplier Using Linear and Saturation Regions of MOSFET Complementally(Special Section on Papers Selected from ITC-CSCC 2001)
• Wobble modification defect in tRNA disturbs codon-anticodon interaction in a mitochondrial disease
• Modification Defect at Anticodon Wobble Nucleotide of Mitochondrial tRNAs^(UUR) with Pathogenic Mutations of Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episodes
• Production of Crystallized Carbon for Electromagnetic Shielding from Lignocresol by Nickel-Catalyzed Carbonization : Influence of Calcium Co-loading (I)
• Nickel-Catalyzed Carbonization of Lignocresol to Produce Crystallized Carbon Usable for Electromagnetic Shielding
• Y-27632 augments the isoflurane-induced relaxation of bronchial smooth muscle in rats
• A NEW APPROACH FOR ASSESSMENT OF NARCOTIC PHYSICAL DEPENDENCE USING URINARY SEX-DEPENDENT LOW MOLECULAR WEIGHT PROTEINS IN MALE RATS
• On the Dynamical Tendency of Intuitively Designed Shapes
• EFFECTS OF NIFEDIPINE ON PHYSICAL DEPENDENCE ON BARBITAL OR DIAZEPAM IN RATS
• The role of RhoA-mediated Ca^ sensitization of bronchial smooth muscle contraction in airway hyperresponsiveness
• Hyperactivity in novel environment with increased dopamine and impaired novelty preference in apoptosis signal-regulating kinase 1 (ASK1)-deficient mice
• S9-4 Molecular mechanism of changes in the morphine-induced rewarding effect under chronic pain-like state : Suppression of dopaminergic transmission in the brain(SYMPOSIUM 9: MOLECULAR MECHANISMS OF DRUG DEPENDENCE)(Proceedings of the 31st Annual Meeting
• Chronic treatment with diphenylarsinic acid (DPAA) affects central nerves system(Proceedings of the 32nd Annual Meeting)
• Thymic Adenocarcinoma with Sarcomatoid Features Characterized by Intracaval Tumor Growth : Report of a Case
• EATING BEHAVIOR REVEALS RATS PREFERENCE FOR MORPHINE
• Effects of κ-Agonist on the Antinociception and Locomotor Enhancing Action Induced by Morphine in Mice
• Identification and Characterization of Rat RhoA Gene Promoter
• Effects of Antiallergic Drugs on Bronchial and Cutaneous Anaphylaxes in Lewis Rats
• EFFECTS OF EXPECTORANTS ON THE CANINE TRACHEAL CILIATED CELLS
• EFFECTS OF QUINIDINE AND CIMETIDINE ON METHAMPHETA MINE STEREOTYPY IN RATS
• Contribution of Glutamate Receptors to Benzodiazepine Withdrawal Signs
• Possible Involvements of Nuclear Factor-κB and Activator Protein-1 in the Tumor Necrosis Factor-α-Induced Upregulation of Matrix Metalloproteinase-12 in Human Alveolar Epithelial A549 Cell Line
• High Catalytic Activity of Ion-Exchanged Nickel on Carboxymethylated Wood Char in Methanation of Carbon Monoxide
• Upregulation of geranylgeranyltransferase I in bronchial smooth muscle of mouse experimental asthma: its inhibition by lovastatin
• Phosphorylation of signal transducer and activator of transcription 6 (STAT6) and STAT1, but not STAT3, induced by antigen inhalation in bronchial smooth muscles of sensitized mice
• Activation of signal transducer and activator of transcription factor 1 by interleukins-13 and -4 in cultured human bronchial smooth muscle cells
• Inhibition of antigen-induced bronchial smooth muscle hyperresponsiveness by lovastatin in mice
• PHYSICAL DEPENDENCE ON MORPHINE, PHENOBARBITAL AND DIAZEPAM IN RATS BY DRUG-ADMIXED FOOD INGESTION
• CROSS-CEPENDENCE BETWEEN PHENOBARBITAL AND ALCOHOL IN RATS
• PREFERENCE FOR MORPHINE AND DRUG-SEEKING BEHAVIOR IN MORPHINE DEPENDENT RATS
• EATING PATTERN OF MORPHINE DEPENDENT RATS
• ORAL SELF-ADMINISTRATION OF MORPHINE IN RATS
• P-II-A-7 Caffeine's (CAF) Effect on Methamphetamine (MAP), Cocaine (CAN), Morphine(MRP) and Pentobarbital(PTB)-induced Conditioned Place Preference in Mice. 日本動物心理学会第51回大会発表要旨
• P-II-5 The Effect of Methamphetamine and Caffeine on Place Preference Conditioning(日本動物心理学会第50回大会発表)
• Different effects of smoke from heavy and light cigarettes on the induction of bronchial smooth muscle hyperresponsiveness in rats
• Acetylcholine-Induced Smooth Muscle Contraction of Intrapulmonary Small Bronchi Is Augmented in Antigen-Induced Airway Hyperresponsive Rats
• MicroRNAs and Their Therapeutic Potential for Human Diseases : MiR-133a and Bronchial Smooth Muscle Hyperresponsiveness in Asthma
• Hydrogasification of wood for high heating-value gas production X : Effect of pretreatment of Japanese oak bark by HNO_3 oxidation on subsequent iron-catalyzed hydrogasification
• SKI-II, an Inhibitor of Sphingosine Kinase, Ameliorates Antigen-Induced Bronchial Smooth Muscle Hyperresponsiveness, but Not Airway Inflammation, in Mice
• RhoA, a Possible Target for Treatment of Airway Hyperresponsiveness in Bronchial Asthma
• Discriminative Stimulus Effects of Hallucinogenic Drugs: a Possible Relation to Reinforcing and Aversive Effects
• Antitussive effect of RU-20201 - Central and peripheral actions.
• The role of vagal reflex in mechanism of secretagogic action of bromhexine.

もっと見る 閉じる

スポンサーリンク