Recent Advances in the Search for the μ-Opioidergic System : Differential Mechanism of G-Protein Activation Induced Endogenous μ-Opioid Peptides, Endomorphin and β-Endomorphin
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概要
- 論文の詳細を見る
It is well documented that the μ-opioid receptor (MOP-R) is expressed by neurons in several central nervous system regions. Its occupancy with agonist drugs modulate a variety of physiological processes including pain, reward, stress, immune responses, neuroendocrine functions, and cardiovascular control. Based on the receptor binding assay, endomorphin-1 and endomorphin-2 have the highest specificity and affinity for the MOP-R of any endogenous substance so far described in the mammalian nervous system. In contrast, β-endorphin exhibits the strongest actions among endogenous opioid peptides mainly through the MOP-R; however, it also shows the distinct pharmacological actions. Recent cloning and expression studies have indicated that MOP-Rs are seven-transmembrane domain receptors whose actions are mediated through activation of heterotrimeric guanine nucleotide binding proteins (G-proteins). The activation of G-proteins by MOP-Rs can be measured by assessing agonist-induced stimulation of membrane binding of guanosine-5-o-(3-[35S]thio)triphosphate ([35S]GTPγS). The subject of the present review is to focus on the differential mechanism underlying G-protein activation induced by these μ-opioid peptides using the [35S]GTPγS binding assay.
- 社団法人 日本薬理学会の論文
- 2002-07-01
著者
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SUZUKI Tsutomu
Department of Applied and Environmental Chemistry, Kitami Institute of Technology
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Tseng L
Department Of Anesthesiology Medical College Of Wisconsin
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Tseng Leon
Department Of Anesthesiology Medical College Of Wisconsin
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Sawaguchi T
Department Of Emergency Medicine Tokyo Women's Medical University
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NARITA Minoru
Department of Toxicology, School of Pharmacy, Hoshi University
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MIZOGUCHI Hirokazu
Department of Physiology and Anatomy, Tohoku Pharmaceutical University
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SORA Ichiro
Department of Psychopharmacology, Tokyo Institute of Psychiatry
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Sora Ichiro
Department Of Psychopharmacology Tokyo Institute Of Psychiatry
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Nomura Mutsuko
Department Of Toxicology Hoshi University School Of Pharmacy And Pharmaceutical Sciences
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Sora Ichiro
Department Of Internal Medicine General Minami Tohoku Hospital
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Namiki Mizuho
Dep. Of Emergency Medicine Tokyo Women's Medical Univ. Jpn
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Namiki Mizuho
Department Of Emergency Medicine Tokyo Women's Medical University
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Narita Minoru
Department Of Emergency Medicine Tokyo Women's Medical University
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Mizoguchi Hirokazu
Department Of Anesthesiology Medical College Of Wisconsin
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Narita Minoru
Department Of Anesthesiology Medical College Of Wisconsin
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Nomura Mutsuko
Department Of Emergency Medicine Tokyo Women's Medical University
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Sora Ichiro
Department Of Biology Psychiatry Tohoku University Graduate School Of Medicine Tohoku University
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Suzuki Tsutomu
Department Of Applied And Environmental Chemistry Kitami Institute Of Technology
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Sora Ichiro
Department of Biological Psychiatry, Graduate School of Medicine, Tohoku University
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