Animal Models of Attention-Deficit/Hyperactivity Disorder
スポンサーリンク
概要
- 論文の詳細を見る
Attention-deficit hyperactivity disorder (AD/HD) is a clinically heterogenous disorder including hyperactivity, impulsivity, and inattention. Both psychostimulant and non-psychostimulant drugs such as methylphenidate and atomoxetine, respectively, to modulate catecholeamine neurotransmission are used as current pharmacotherapies for AD/HD. Multiple lines of evidence suggest that genetic factors play major roles in the etiology of AD/HD. meta-Analyses and pooled data analyses have suggested associations between AD/HD and polymorphisms in genes encoding monoamine neurotransmission molecules. There has been considerable research on this disorder using genetic, pharmacological, and neuroimaging approaches, and several animal models of AD/HD such as spontaneously hypertensive rat (SHR), dopamine transporter (DAT) knockout mice, coloboma mutant mouse, and Grin1 mutant mouse have been reported. These animal models are valuable tools for investigating molecular, cellular, and behavioral mechanisms as well as the neural development and circuit mechanisms of AD/HD. Here, we review the recent literature on animal models of AD/HD and discuss their advantages and limitations.
著者
-
Sora Ichiro
Department of Biological Psychiatry, Graduate School of Medicine, Tohoku University
-
Arime Yosefu
Department of Biological Psychiatry, Graduate School of Medicine, Tohoku University
-
Kubo Yumiko
Department of Biological Psychiatry, Graduate School of Medicine, Tohoku University
関連論文
- Lack of μ-Opioid Receptor-Mediated G-Protein Activation in the Spinal Cord of Mice Lacking Exon 1 or Exons 2 and 3 of the MOR-1 Gene
- FUNCTIONAL ANALYSIS OF GRAVITY-SENSE GENES IN THE ASCIDIAN LARVA(Physiology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- Recent Advances in the Search for the μ-Opioidergic System : Differential Mechanism of G-Protein Activation Induced Endogenous μ-Opioid Peptides, Endomorphin and β-Endomorphin
- Molecular mechanisms of analgesia induced by opioids and ethanol : is the GIRK channel one of the keys?
- Functional identification of ASCT1 neutral amino acid transporter as the predominant system for the uptake of L-serine in rat neurons in primary culture
- FUNCTIONAL ANALYSIS OF GRAVITY-SENSE GENES IN THE ASCIDIAN LARVA(Physiology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- Effect of Chronic Lithium Treatment on Gene Expression Profile in Mouse Microglia and Brain Dendritic Cells
- Antidepressant-Like Effect of Venlafaxine Is Abolished in μ-Opioid Receptor-Knockout Mice
- Antidepressant-Like Effect of Venlafaxine Is Abolished in μ-Opioid Receptor–Knockout Mice
- Animal Models of Attention-Deficit/Hyperactivity Disorder