Antidepressant-Like Effect of Venlafaxine Is Abolished in μ-Opioid Receptor–Knockout Mice
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概要
- 論文の詳細を見る
Although the opioid system is known to modulate depression-like behaviors, its role in the effects of antidepressants is not yet clear. We investigated the role of μ-opioid receptors (MOPs) in the effects of venlafaxine, a serotonin and norepinephrine reuptake inhibitor, in the forced swim test using MOP–knockout (KO) mice. Venlafaxine reduced immobility time in wild-type mice (C57BL/6J), but not in MOP-KO mice, although no significant effects were observed on locomotor activity. These results suggest that MOPs play an important role in the antidepressant-like effects of venlafaxine.
- 社団法人 日本薬理学会の論文
著者
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Uhl George
Molecular Neurobiology Branch Intramural Research Program National Institute On Drug Abuse National
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Sora Ichiro
Department Of Psychopharmacology Tokyo Institute Of Psychiatry
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Minami Masabumi
Department Of Molecular Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University
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Ide Soichiro
Department Of Molecular Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University
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Fujiwara Masayuki
Laboratory Of Plant Molecular And Plant Protein Analysis Plant Science Education Unit Graduate Schoo
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Ikeda Kazutaka
Division Of Psychobiology Tokyo Institute Of Psychiatry
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Sora Ichiro
Department Of Biology Psychiatry Tohoku University Graduate School Of Medicine Tohoku University
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Ishihara Kumatoshi
Laboratory Of Neuropharmacology Faculty Of Pharmaceutical Sciences Hiroshima International Universit
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Fujiwara Shunsuke
Lahoratory Of Neuropharmacology Faculty Of Pharmaceutical Sciences Hiroshima International Universit
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Fujiwara Shunsuke
Laboratory of Neuropharmacology, Faculty of Pharmaceutical Sciences, Hiroshima International Univers
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Fujiwara Masayuki
Lahoratory Of Neuropharmacology Faculty Of Pharmaceutical Sciences Hiroshima International Universit
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Ishihara Kumatoshi
Laboratory of Neuropharmacology, Faculty of Pharmaceutical Sciences, Hiroshima International University, Japan
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Fujiwara Masayuki
Laboratory of Neuropharmacology, Faculty of Pharmaceutical Sciences, Hiroshima International University, Japan
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Sora Ichiro
Department of Biological Psychiatry, Graduate School of Medicine, Tohoku University
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Minami Masabumi
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Japan
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Uhl George
Molecular Neurobiology, National Institute on Drug Abuse, USA
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Ide Soichiro
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Japan
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Fujiwara Shunsuke
Laboratory of Neuropharmacology, Faculty of Pharmaceutical Sciences, Hiroshima International University, Japan
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IDE SOICHIRO
Department of Medicine, Kurume University School of Medicine
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