Roles of β- and α2-Adrenoceptors Within the Central Nucleus of the Amygdala in the Visceral Pain–Induced Aversion in Rats
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概要
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We investigated the roles of β- and α2-adrenoceptors within the central nucleus of the amygdala (CeA) in the negative affective and sensory components of visceral pain in rats. We observed a dose-dependent reduction of intraperitoneal acetic acid-induced conditioned place aversion by bilateral injections of timolol, a β-adrenoceptor antagonist, or clonidine, an α2-adrenoceptor agonist, without reducing writhing behaviors. These data suggest a pivotal role of intra-CeA adrenoceptors in the negative affective, but not sensory, component of visceral pain.
- 社団法人 日本薬理学会の論文
著者
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Nakagawa Takayuki
Department Of Fisheries Faculty Of Agriculture Kinki University
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Minami Masabumi
Department Of Molecular Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University
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DEYAMA Satoshi
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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TANIMOTO Sachi
Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
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TAKISHITA Azusa
Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
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Satoh Masamichi
Department Of Molecular Pharmacology Faculty Of Pharmaceutical Science Kyoto University
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Ide Soichiro
Department Of Molecular Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University
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Satoh Masamichi
Department Of Hygiene And Preventive Medicine Faculty Of Medicine Saitama Medical School
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Tanimoto Sachi
Department Of Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
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Deyama Satoshi
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Hokkaido University
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Takishita Azusa
Department Of Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
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