Possible Involvement of Descending Serotonergic Systems in Antinociception by Centrally Administered Elcatonin in Mice
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概要
- 論文の詳細を見る
To elucidate the mechanisms of analgesic action of elcatonin, a synthetic analog of eel calcitonin, the effect of centrally injected elcatonin on acetic acid-induced writhing behavior was examined in mice. Intracisternal or intracerebroventricular injection of elcatonin significantly inhibited acetic acid-induced writhing behavior, while the intrathecal injection of elcatonin did not inhibit it. The inhibitory effect of intracisternal elcatonin was significantly attenuated by subcutaneous pretreatment with methysergide and (±)-propranolol or by intrathecal pretreatment with methysergide, (±)-propranolol, 1-(2-methoxyphenyl)-4-[4-(2-phthalimido) butyl]-piperazine hydrobromide (NAN-190) and granisetron, but not with (±)-atenolol or butoxamine. Further, the depletion of spinal 5-hydroxytryptamine (5-HT, serotonin) by pretreatment with 5,7-dihydroxytryptamine (5,7-DHT) significantly attenuated the inhibitory effect of intracisternally injected elcatonin on acetic acid-induced writhing behavior. These results suggest that the inhibitory descending serotonergic systems may be involved, through 5-HT_<1A> and 5-HT_3 receptors, in the production of an antinociceptive effect by centrally injected elcatonin.
- 公益社団法人日本薬学会の論文
- 1999-07-15
著者
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Seki Takahiro
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
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Satoh Masamichi
Department Of Molecular Pharmacology Faculty Of Pharmaceutical Science Kyoto University
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Watanabe Takeshi
Department Of Applied Biological Chemistry Faculty Of Agriculture Niigata University
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NAKAMOTO Hiromitsu
Department of Molecular Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University
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SOEDA Yuko
Department of Molecular Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University
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Seki Takahiro
Department Of Computer Science Tokyo Institute Of Technology:(present Address)ibm Global Service-jap
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Soeda Yuko
Department Of Molecular Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University
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Satoh Masamichi
Department Of Hygiene And Preventive Medicine Faculty Of Medicine Saitama Medical School
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Nakamoto Hiromitsu
Department Of Molecular Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University
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Watanabe Takeshi
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University
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Watanabe Takeshi
Department Of Molecular Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University
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Seki Takahiro
Department Of Applied Physics Nagoya University
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