Antinociceptive Effects of Oriental Medicine Kei-Kyoh-Zoh-Soh-Oh-Shin-Bu-toh in Mice and Rats

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Antinociceptive effects of peroral administration of an oriental medicine Kei-Kyoh-Zoh-Soh-Oh-Shin-Bu-toh (TJ-8023) were examined using rats and mice. TJ-8023 (100mg・kg^<-1>・d^<-1>) inhibited the induction of adjuvant-induced hyperalgesia of rats in the paw-pressure test following prophylactic administration, and normalized the nociceptive threshold at a dose of 600 mg・kg^<-1>・d^<-1>, without effects on adjuvant-induced inflammation. Mice suffering from repeated cold stress showed a decrease in nociceptive threshold for tail-pressure stimulation. Such a hyperalgesia was reversed by a single (30 and 100mg/kg) or repeated administration (100 and 300 mg・kg^<-1>・d^<-1>) of TJ-8023. The nociceptive threshold of non-stressed mice was not affected by TJ-8023 (100mg/kg). Nociceptive responses of mice to cold-plate stimulation were also not affected by repeated administration of TJ-8023 (300,600 and 1200 mg・kg^<-1>・d^<-1>). The present results demonstrate the antinociceptive action of TJ-8023,and suggest that it is more effective in easing a hyperalgesia in morbid state than in suppressing a nociception in the normal one.
公益社団法人日本薬学会の論文