Effects of Naltrexone on Spontaneous Itch-Associated Responses in NC Mice With Chronic Dermatitis
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概要
- 論文の詳細を見る
The effects of the opioid antagonist naltrexone on spontaneous itch-associated behaviors and cutaneous nerve activities were examined to determine whether it inhibits pruritus through peripheral action in NC mice with chronic dermatitis. Their rostral-back scratching and caudal-back biting were 19 and 3.4 times more, respectively, than those of control mice. The activities of cutaneous nerves innervating the rostral and caudal back were 9.5 and 5.4 times more, respectively, in affected mice than in control mice. Subcutaneous injections of naltrexone significantly inhibited the scratching and biting, without effects on the nerve activities. The results suggest that the peripheral action does not play a central role in inhibiting chronic itch-associated behaviors.
- 社団法人 日本薬理学会の論文
- 2002-10-01
著者
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NOJIMA Hiroshi
Department of Pharmacology, School of Pharmaceutical Sciences, Ohu University
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KURAISHI Yasushi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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YAMAGUCHI-MIYAMOTO Tomomi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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Kuraishi Yasushi
Department Of Applied Pharmacology Graduate School Of Medical And Pharmaceutical Science University
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Kuraishi Yasushi
富山大学 医学薬学研究部応用薬理学
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Kuraishi Yasushi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Nojima H
Department Of Pharmacology School Of Pharmaceutical Sciences Ohu University
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Nojima Hiroshi
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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MAEKAWA Tatsuya
Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceu
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Maekawa Tatsuya
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Nojima Hiroshi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Ohu University
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Yamaguchi-miyamoto Tomomi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Nojima Hiroshi
Faculty Of Horticulture Chiba University
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Nojima Hiroshi
Department Of Molecular Generics Research Institute For Microbial Diseases Osaka University
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Nojima H
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Kuraishi Yasushi
Department Of Applied Pharmacology Faculty Of Pharmaceu Tical Sciences
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Kuraishi Yasushi
Department Of Applide Biochemistry Research Institute For Wakan-yaku Toyama Toyama Medical And Pharm
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Nojima Hiroshi
Laboratory Of Medical Chemistry Graduate School Of Medicine And Pharmaceutical Sciences University O
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Nagai Hiroichi
Pharmacological Department Gifu College Of Pharmacy
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