Primary structure of the .ALPHA.-subunit of human Na,K-ATPase deduced from cDNA sequence.
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概要
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Clones carrying cDNA sequences for the α-subunit of the Na, K-ATPase from HeLa cells have been isolated. Nucleotide sequence analysis of the cloned cDNA has revealed the primary structure of this polypeptide, which consists of 1, 023 amino acids. The α-subunit of the human Na, K-ATPase exhibited 87% homology with its Torpedo counterpart and 98% homology with its sheep counterpart. The six putative transmembrane segments M1-M6 showed higher conservation than the total segments. Total genomic Southern hybridization indicated the existence of at most two copies, possibly only one, of the gene encoding the Na, K-ATPase α-subunit in the human genome.
- 社団法人 日本生化学会の論文
著者
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Nojima Hiroshi
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Ohta Toshiko
Department Of Biology Jichi Medical School
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Kawakami Kiyoshi
Department Of Biology Jichi Medical School
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OHTA Toshiko
Departments of Biology Jichi Medical School
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NAGANO Kei
Departments of Biology Jichi Medical School
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