A Mouse Model of Sural Nerve Injury–Induced Neuropathy: Gabapentin Inhibits Pain-Related Behaviors and the Hyperactivity of Wide-Dynamic Range Neurons in the Dorsal Horn
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概要
- 論文の詳細を見る
This study was conducted to make a new mouse model of neuropathic pain due to injury to a branch of the sciatic nerve. One of three branches (sural, tibial, and common peroneal nerves) of the sciatic nerve was tightly ligated, and mechanical and cool stimuli were applied to the medial part (tibial and common peroneal nerve territories) of the plantar skin. The three types of nerve injuries produced behavioral mechanical hypersensitivities, and the extent of the hypersensitivities after sural and tibial nerve ligation was larger than that of common peroneal nerve ligation. Sural nerve ligation did not affect motor function of the affected hind paw, but tibial and common peroneal nerve ligation produced motor dysfunction. These results suggest that the ligation of the sural nerve is the most suitable for behavioral study. Sural nerve ligation induced behavioral hypersensitivities to mechanical and cool stimuli, which were almost completely inhibited by gabapentin (30 mg/kg). Sural nerve ligation increased spontaneous activity and responses of the wide-dynamic range neurons in the lumbar dorsal horn, which were also almost completely inhibited by gabapentin (30 mg/kg). Sural nerve ligation provides a new mouse model of neuropathic pain, which is easy to prepare and sensitive to gabapentin.
- 社団法人 日本薬理学会の論文
著者
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OMORI Yu
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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KAGAYA Kenta
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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ENOMOTO Ryugo
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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SASAKI Atsushi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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ANDOH Tsugunobu
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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NOJIMA Hiroshi
Department of Pharmacology, School of Pharmaceutical Sciences, Ohu University
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TAKAHATA Hiroki
Department of Pharmaceutical Chemistry, Tohoku Pharmaceutical University
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KURAISHI Yasushi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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Kagaya Kenta
Dep. Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Univ. Of Toyama
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Kagaya Kenta
富山大学 医学薬学研究部応用薬理学
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Kagaya Kenta
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Omori Yu
Dep. Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Univ. Of Toyama
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Omori Yu
富山大学 医学薬学研究部応用薬理学
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Omori Yu
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Nojima Hiroshi
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Enomoto Ryugo
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Sasaki Atsushi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Andoh Tsugunobu
Department Of Applied Pharmacology Faculty Of Pharmaceu Tical Sciences
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Takahata Hiroki
Department Of Pharmaceutical Chemistry Tohoku Pharmaceutical University
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Kuraishi Yasushi
Department Of Applied Pharmacology Faculty Of Pharmaceu Tical Sciences
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Kuraishi Yasushi
Department Of Applide Biochemistry Research Institute For Wakan-yaku Toyama Toyama Medical And Pharm
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Takahata Hiroki
Department of Organochemical Design and Synthesis,Faculty of Pharmaceutical Sciences,Toyama Medical and Pharmaceutical University,2630 Sugitani,Toyama 930-0194,Japan
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Kuraishi Yasushi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
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Kagaya Kenta
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
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Takahata Hiroki
Department of Pharmaceutical Chemistry, Tohoku Pharmaceutical University, Japan
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Omori Yu
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
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