Central Nervous System Lymphoma Initially Diagnosed as Tumefactive Multiple Sclerosis after Brain Biopsy
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概要
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A 72-year-old man was admitted with left homonymous hemianopsia and hemiparesis. Magnetic resonance imaging revealed a heterogeneously enhanced lesion in the right parietal lobe. A brain biopsy showed acute demyelination without malignancy, which led to a diagnosis of tumefactive multiple sclerosis (MS). The patient received corticosteroid therapy and experienced clinical and radiological improvement. Six months later, new lesions appeared, and a second biopsy revealed proliferation of dysplastic lymphocytes. This led to a revised diagnosis of primary central nervous system lymphoma (PCNSL). Because PCNSL mimics MS both clinically and radiologically, PCNSL is difficult to diagnose. Performing repeated brain biopsies may therefore be required when PCNSL is strongly suspected.
著者
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Uchino Akira
Department Of Agrobiology Faculty Of Agriculture University Of Tokyo
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Sasaki Atsushi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Tanahashi Norio
Department Of Anesthesiology Osaka University Medical School
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Hayashi Takeshi
Department Of Computer Science And Systems Engineering Graduate School Of Engineering Kobe Universit
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Matsuda Hiroshi
Department Of Anatomy Osaka University Medical School
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Mishima Kazuhiko
Department Of Neurosurgery Saitama Medical University
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Nishikawa Ryo
Department Of Chemistry Graduate School Of Science Kyoto University
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Ohe Yasuko
Department of Neurology and Cerebrovascular Medicine, Saitama Medical University International Medical Center, Japan
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Uchino Akira
Department of Diagnostic Radiology, Saitama Medical University International Medical Center, Japan
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Mishima Kazuhiko
Department of Neuro-Oncology, Saitama Medical University International Medical Center, Japan
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Nishikawa Ryo
Department of Neuro-Oncology, Saitama Medical University International Medical Center, Japan
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Sasaki Atsushi
Department of Pathology, Saitama Medical University, Japan
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