Cilostazol inhibits leukocyte-endothelial cell interactions in murine microvessels after transient bilateral common carotid artery occlusion
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概要
- 論文の詳細を見る
Leukocyte behavior in the cerebral microvasculature following vessel occlusion has not been fully elucidated. The purpose of this study was to investigate the effects of cilostazol on leukocyte behavior (rolling and adhesion) in murine cerebral microvessels following transient bilateral carotid artery occlusion using intravital fluorescence microscopy. Four groups of mice were assigned: a sham group (n=16); an ischemia (induced by 15-min occlusion of bilateral common carotid arteries) and reperfusion (I/R) group (n=13); I/R+cilostazol (I/R+CZ3mg/kg) group (I/R after oral administration of cilostazol at 3mg/kg) (n=8) and I/R+cilostazol (I/R+CZ30mg/kg) group (I/R after oral administration of cilostazol at 30mg/kg) (n=12). Leukocytes labeled with 0.05% acridine orange were administered intravenously and their behavior was investigated at 3 and 6 h after reperfusion. Numbers of rolling or adherent leukocytes were expressed as the count per square millimeter per 30s. Numbers of rolling and adherent leukocytes at 3 and 6h after reperfusion were significantly higher in the I/R group than in the sham or I/R+CZ30mg/kg groups in both pial veins (P<0.05) and pial arteries (P<0.05). Cilostazol (30mg/kg) inhibited leukocyte-endothelial interactions following cerebral ischemia and reperfusion.
- 日本微小循環学会の論文
著者
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Tanahashi Norio
Department Of Anesthesiology Osaka University Medical School
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Fukuoka Takuya
Department Of Marine Biotechnology Faculty Of Engineering Fukuyama University
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Hayashi Takeshi
Department Of Computer Science And Systems Engineering Graduate School Of Engineering Kobe Universit
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Maruyama Hajime
Department of Neurology and Cerebrovascular Medicine, Saitama International Medical Center, Saitama Medical University
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Tanahashi Norio
Department of Neurology, Saitama Medical University International Medical Center
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Fukuoka Takuya
Department of Neurology, Saitama Medical University International Medical Center
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Hirayama Makiko
Department of Neurology, Saitama Medical University International Medical Center
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