Blockade of Glycine Transporter (GlyT) 2, but Not GlyT1, Ameliorates Dynamic and Static Mechanical Allodynia in Mice With Herpetic or Postherpetic Pain
スポンサーリンク
概要
- 論文の詳細を見る
Glycine is an inhibitory neurotransmitter in the spinal dorsal horn and its extracellular concentration is regulated by glial glycine transporter (GlyT) 1 and neuronal GlyT2. This study was conducted to elucidate the effects of intrathecal injections of GlyT1 and GlyT2 inhibitors on two distinct types of mechanical allodynia, dynamic and static allodynia, in mice with herpetic or postherpetic pain. The GlyT2 inhibitor ALX1393, but not the GlyT1 inhibitor sarcosine, suppressed dynamic and static allodynia at the herpetic and postherpetic stages. Intrathecal ALX1393 suppressed dynamic allodynia induced by intrathecal strychnine and N-methyl-D-aspartate (NMDA). Intrathecal sarcosine suppressed dynamic allodynia induced by intrathecal strychnine, but not NMDA. Expression level of GlyT1, but not GlyT2, mRNA in the lumbar dorsal horn was decreased at the herpetic and postherpetic stages. Glycine receptor α1-subunit mRNA was decreased in the lumbar dorsal horn at the herpetic, but not postherpetic stage, without alteration in α3-subunit mRNA. The results suggest that GlyT2 is a potential target for treatment of dynamic and static allodynia in patients with herpes zoster and postherpetic neuralgia. The lack of efficacy of GlyT1 inhibitor may be explained by activation of NMDA receptors and the down-regulation of GlyT1 in the lumbar dorsal horn.
- 社団法人 日本薬理学会の論文
著者
-
SASAKI Atsushi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
-
KURAISHI Yasushi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
-
Kuraishi Yasushi
富山大学 医学薬学研究部応用薬理学
-
Sasaki Atsushi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
-
Kuraishi Yasushi
Department Of Applied Pharmacology Faculty Of Pharmaceu Tical Sciences
-
Nishikawa Yukitoshi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
-
Sasaki Atsushi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
-
Kuraishi Yasushi
Department Of Applide Biochemistry Research Institute For Wakan-yaku Toyama Toyama Medical And Pharm
-
Kuraishi Yasushi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
-
Nishikawa Yukitoshi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
-
Kuraishi Yasushi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
-
Sasaki Atsushi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
-
Nishikawa Yukitoshi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
関連論文
- Pharmacological Evaluation of Analgesic Effects of the Cholecystokinin2 Receptor Antagonist Z-360 in Mouse Models of Formalin- and Cancer-Induced Pain
- Involvement of Endothelin and ET_A Endothelin Receptor in Mechanical Allodynia in Mice Given Orthotopic Melanoma Inoculation
- A Mouse Model of Sural Nerve Injury-Induced Neuropathy : Gabapentin Inhibits Pain-Related Behaviors and the Hyperactivity of Wide-Dynamic Range Neurons in the Dorsal Horn
- Intracisternal, But Not Intrathecal, Injection of Naloxone Inhibits Cutaneous Itch-Related Response in Mice(Pharmacology)
- Inhibitory Mechanisms of Glycoprotein Fraction Derived from Miscanthus sinensis for the Immediate Phase Response of an IgE-Mediated Cutaneous Reaction
- Evidence for Separate Involvement of Different μ-Opioid Receptor Subtypes in Itch and Analgesia Induced by Supraspinal Action of Opioids
- Pharmacological Evaluation of Morphine and Non-opioid Analgesic Adjuvants in a Mouse Model of Skin Cancer Pain(Pharmacology)
- Possible Involvement of 5-Lipoxygenase Metabolite in Itch-Associated Response of Mosquito Allergy in Mice
- Repeated Treatment With the Traditional Medicine Unsei-in Inhibits Substance P-Induced Itch-Associated Responses Through Downregulation of the Expression of Nitric Oxide Synthase 1 in Mice
- Inhibitory Effect of the Repeated Treatment with Unsei-in on Substance P-Induced Itch-Associated Responses through the Downregulation of the Expression of NK_1 Tachykinin Receptor in Mice
- Suppression by Gabapentin of Pain-Related Mechano-Responses in Mice Given Orthotopic Tumor Inoculation
- Inhibitory Effect of Azelastine on Allergic Itch-Associated Response in Mice Sensitized With Mosquito Salivary Glands Extract
- A Mouse Model of Sural Nerve Injury–Induced Neuropathy: Gabapentin Inhibits Pain-Related Behaviors and the Hyperactivity of Wide-Dynamic Range Neurons in the Dorsal Horn
- Mechanical Allodynia Induced by Paclitaxel, Oxaliplatin and Vincristine : Different Effectiveness of Gabapentin and Different Expression of Voltage-Dependent Calcium Channel α_2δ-1 Subunit(Pharmacology)
- Proliferation and cell death of human glioblastoma cells after carbon-ion beam exposure : Morphologic and morphometric analyses
- Involvement of Tryptase and Proteinase-Activated Receptor-2 in Spontaneous Itch-Associated Response in Mice With Atopy-like Dermatitis
- Capsaicin-Sensitivity of Acutely Dissociated Dorsal Root Ganglion Neurons of Mice
- Conversion of aconitine lipoaconitine by human intestinal bacteria and their antinociceptive effects in mice
- Expression of p73 in normal skin and proliferative skin lesions
- Differential labeling of the pinealocytes and pineal interstitial cells by a series of monoclonal antibodies to human pineal body
- Diversity of glial cell components in pilocytic astrocytoma
- Dual effect of serotonin on formalin-induced nociception in the rat spinal cord
- Effects of the Prostaglandin E_1 Analog Limaprost on Mechanical Allodynia Caused by Chemotherapeutic Agents in Mice
- Activation of Proteinase-Activated Receptors Induces Itch-Associated Response Through Histamine-Dependent and -Independent Pathways in Mice
- Pharmacological Differences Between Static and Dynamic Allodynia in Mice With Herpetic or Postherpetic Pain
- Effects of Topical Application of Tacrolimus on Acute Itch-Associated Responses in Mice(Pharmacology)
- Effects of Loperamide on Mechanical Allodynia Induced by Herpes Simplex Virus Type-1 in Mice
- Roles of α-Adrenoceptors and Sympathetic Nerve in Acute Herpetic Pain Induced by Herpes Simplex Virus Inoculation in Mice
- Mechanical Hypersensitivity and Alterations in Cutaneous Nerve Fibers in a Mouse Model of Skin Cancer Pain
- Effects of Naltrexone on Spontaneous Itch-Associated Responses in NC Mice With Chronic Dermatitis
- Inhibitory Effect of Methanol Extract of Ganoderma lucidum on Acute Itch-Associated Responses in Mice
- Algogenic effects of Extract of the Tumor Mass Isolated from Mice with Orthotopic Melanoma Inoculation
- Retrorectal Epidermoid Cyst in an Elderly Woman : Report of a Case
- Roles of Mast Cells and Histamine in Mosquito Bite-Induced Allergic Itch-Associated Responses in Mice
- Caffeine inhibits paresthesia indced by herpes simlpex virus through action on primary sensory neurons in rats
- Itch-Associated Response Induced by Experimental Dry Skin in Mice
- Intradermal Cholinergic Agonists Induce Itch-Associated Response via M_3 Muscarinic Acetylcholine Receptors in Mice
- Characterization of itch-associated responses of NC mice with mite-induced chronic dermatitis
- Itch-Associated Responses of Afferent Nerve Innervating the Murine Skin: Different Effects of Histamine and Serotonin in ICR and ddY Mice
- Induction by carrageenan inflammation of prepronociceptin mRNA in VR1-immunoreactive neurons in rat dorsal root ganglia
- Pharmacological and Immunohistochemical Characterization of a Mouse Model of Acute Herpetic Pain
- Inhibitory Effects of the Methanol Extract of Ganoderma lucidum on Mosquito Allergy–Induced Itch-Associated Responses in Mice
- Tonic Inhibition of Allergic Itch Signaling by the Descending Noradrenergic System in Mice
- Design of 1m^2 Order Plasma Excitation Single-Layer Slotted Waveguide Array with Conducting Baffles and Quartz Glass Strips Using the GSM-MoM Analysis(Antennas and Propagation)
- Effect of repeated cold stress on capsaicin-evoked release of glutamate from rat spinal dorsal horn slices
- Pineal parenchymal tumor of intermediate differentiation with cytologic pleomorphism
- Immunohistochemical analysis of cleaved caspase-3 detects high level of apoptosis frequently in diffuse large B-cell lymphomas of the central nervous system
- Flexible Adiabatic Light Guide of Silicon Rubber
- Effects of the Prostaglandin E1 Analog Limaprost on Mechanical Allodynia Caused by Chemotherapeutic Agents in Mice
- Improved Bioassay for the Detection of Transforming Growth Factor-β1 and β2 in Malignant Gliomas
- Peripheral and Central Actions of Capsaicin and VR1 Receptor
- Antinociceptive Effects of Oriental Medicine Kei-Kyoh-Zoh-Soh-Oh-Shin-Bu-toh in Mice and Rats
- SF-018-2 Modulated mRNA Expression of Pyrimidine Catabolic Enzymesby C-IFN on Human Hepatoma Cells
- Photoproduction of η Mesons from Protons at Incident Energies below 1 GeV
- Photoproduction of Positive and Negative Pions from Protons in the Energy Range from 710 MeV to 950 MeV
- Photon Tagging System at the INS Electron Synchrotron
- The Totel Absorption Cross Section of 250-550 MeV Photons in Carbon, Aluminium and Copper
- Serotonin-induced Biting of the Hind Paw is Itch-related Response in Mice
- Primary Bilateral Adrenal Diffuse Large B-cell Lymphoma Demonstrating Adrenal Failure
- Inhibitory Effects of Methanol Extracts of Herbal Medicines on Substance P-Induced Itch-Scratch Response
- Inhibition of Itch-Scratch Response by Fruits of Cnidium monnieri in Mice
- The immunophenotype of perivascular cells in the human brain
- Analysis of Dissociated Single Neurons by Simple and Semi-Quantitative: RT-PCR (Reverse Transcription and Polymerase Chain Reaction)
- Blockade of Glycine Transporter (GlyT) 2, but Not GlyT1, Ameliorates Dynamic and Static Mechanical Allodynia in Mice With Herpetic or Postherpetic Pain
- Itch : Associated Response and Antinociception Induced by Intracisternal Endomorphins in Mice
- Itch-associated response induced by intradermal serotonin through 5-HT_2 receptors in mice
- Different Effects of Intrathecal Neurotoxins fot serotonergic and Catecholaminergic Systems on Antinociceptive Actions of Kei-Kyo-Zoh-Soh-Oh-Shin-Bu-toh and Morphine in Rats
- Involvement of Spinal Substance P and Excitatory Amino Acids in Inflammatory Hyperalgesia in Rats
- Antipruritic Effects of Sophora flavescens on Acute and Chronic Itch-Related Responses in Mice
- Participation of Thrombospondin-1 in the Activation of Latent Transforming Growth Factor-β in Malignant Glioma Cells
- Correlation of thrombospondin-1 and transforming growth factor-β expression with malignancy of glioma
- Clear cell carcinoma of the pancreas : an adenocarinoma with unusual phenotype of duct cell origin
- Analysis of Tumor Necrosis Factor and Lymphotoxin Secreted by Incubation of Lymphokine-activated Killer Cells with Tumor Cells
- Blockade of Glycine Transporter (GlyT) 2, but Not GlyT1, Ameliorates Dynamic and Static Mechanical Allodynia in Mice With Herpetic or Postherpetic Pain
- DIAGNOSTIC USEFULNESS OF LAPAROSCOPIC FINE-NEEDLE ASPIRATION FOR INTRADUCTAL PAPILLARY TUMOR OF THE PANCREAS
- Visualization of glutamate release from rat spinal cord with a confocal laser scanning microscope
- Intracisternal Injection of Opioids Induces Itch-Associated Response through μ-Opioid Receptors in Mice
- NEUROMUSCULAR BLOCKING ACTIONS OF NEUROTOXINS ISOLATED FROM LATICAUDA SEMIFASCIATA, NAJA NAJA AND NAJA NAJA ATRA —A COMPARATIVE ASSAY—
- RE- AND POST-SYNAPTIC ORIGIN OF LITHIUM-INDUCED ACUTE BLOCKADE ON ADRENERGIC TRANSMISSION IN RABBIT HEART
- expression of mRNA for a neuronal differentiation factor, TA20, in developing rat brains
- Involvement of Brain Serotonergic Terminals in the Antinociceptive Action of Peripherally Applied Calcitonin
- Differential diagnosis of CNS lymphomatoid granulomatosis
- Tonic Inhibition of Allergic Itch Signaling by the Descending Noradrenergic System in Mice
- Inhibitory Effects of the Methanol Extract of Ganoderma lucidum on Mosquito Allergy-Induced Itch-Associated Responses in Mice
- EFFECTS OF LOW CONCENTRATIONS OF LITHIUM CHLORIDE ON ADRENERGIC TRANSMISSION IN THE ISOLATED ATRIA OF RABBITS
- Epileptogenic ganglioglioma with hypermetabolism on positron emission tomography with fluorine-18 fluorodeoxyglucose: a case report
- Central Nervous System Lymphoma Initially Diagnosed as Tumefactive Multiple Sclerosis after Brain Biopsy
- Prevention of Topical Surfactant–Induced Itch-Related Responses by Chlorogenic Acid Through the Inhibition of Increased Histamine Production in the Epidermis
- Milnacipran Inhibits Itch-Related Responses in Mice Through the Enhancement of Noradrenergic Transmission in the Spinal Cord
- Prevention of Topical Surfactant-Induced Itch-Related Responses by Chlorogenic Acid Through the Inhibition of Increased Histamine Production in the Epidermis