Antipruritic Effects of Sophora flavescens on Acute and Chronic Itch-Related Responses in Mice
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概要
- 論文の詳細を見る
To find new antipruritic herbal medicines for pruritus, we screened the methanol extracts of seven herbal medicines which have been used to treat dermatologic diseases, testing them on mouse models of acute and chronic itch. When administrated perorally (p.o.) at a dose of 200mg/kg, methanol extracts of Sophora flavescens and Cnidium monnieri, but not the others, significantly inhibited a serotonin (S-HT)-induced itch-related response (scratching) and the spontaneous scratching of NC mice, a mouse model of atopic dermatitis. The inhibitory effect of Sophora flavescens was stronger than that of Cnidium monnieri. The methanol extract from Sophora flavescens (50-200 mg/kg) inhibited 5-HT-induced scratching in a dose-dependent manner, without any eifccts on the locomotor activity. These results suggest that Sophora flavescens and its constituents widely affect acute and chronic pruritus, and are possible as new antipruritic agents.
- 公益社団法人日本薬学会の論文
- 2003-05-01
著者
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KURAISHI Yasushi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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Suzuki Hideyo
Toyama Prefectural Institute For Pharmaceutical Research
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Suzuki H
Toyama Prefectural Inst. Pharmaceutical Res. Toyama Jpn
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Kuraishi Yasushi
Dep. Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Univ. Of Toyama
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KAWASUJI Toru
Toyama Prefectural Institute for Pharmaceutical Research
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Kawasuji T
Toyama Prefectural Institute For Pharmaceutical Research
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Kuraishi Yasushi
Dep. Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Univ. Of Toyama
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Kuraishi Yasushi
Department Of Applied Pharmacology Faculty Of Pharmaceu Tical Sciences
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YAMAGUCHI-MIVAMOTO Tomomi
Japan Society for the Promotion of Science, Domestic Research Fellow
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Suzuki H
Department Of Molecular Biopharmacy And Genetics Graduate School Of Pharmaceutical Sciences Tohoku U
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Suzuki Hideyo
Toyama Prefectural Inst. For Pharmaceutical Res. Toyama Jpn
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Yamaguchi-mivamoto Tomomi
Japan Society For The Promotion Of Science Domestic Research Fellow : Toyama Prefectural Institute F
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Kuraishi Yasushi
Department Of Applide Biochemistry Research Institute For Wakan-yaku Toyama Toyama Medical And Pharm
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Yamaguchi-Miyamoto Tomomi
Japan Society for the Promotion of Science, Domestic Research Fellow
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