Inhibition of Itch-Scratch Response by Fruits of Cnidium monnieri in Mice
スポンサーリンク
概要
- 論文の詳細を見る
We previously screened the anti-itching activities of 33 herbal medicines in substance P(SP)-induced itching model mice. One of the most potent antipruritogenic extracts, the methanol extract of fruits of Cnidium monnieri(Cnidii Fructus)was studied further. The chloroform-soluble fraction of the methanol extract markedly inhibited SP-induced scratching. Among 10 subfractions of the chloroform-soluble fraction, the CS-3 fraction had the most potent inhibitory effect on scratching. Each of 3 subfractions of CS-3 showed significant anti-scratching activities. However, inhibitory potencies were not different among the three and weaker than that of CS-3 itself at a same dose. These 3 subfractions of CS-3 mainly contained xanthotoxin, isopimpinellin, bergapten, imperatorin and osthol. Single administration of osthol did not inhibit SP-induced scratching, and imperatorin very weakly subsided scratching. These results suggest that the strong antipruritic action was focused on the CS-3 fraction of the C.monnieri methanol extract, and it might result from the combined effects of these coumarin derivatives, or by undetermined minor compounds.
- 公益社団法人日本薬学会の論文
- 2001-09-01
著者
-
NOJIMA Hiroshi
Department of Pharmacology, School of Pharmaceutical Sciences, Ohu University
-
KURAISHI Yasushi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
-
Nojima Hiroshi
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
-
Basnet Purusotam
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
-
TOHDA Chihiro
Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical
-
Kuraishi Yasushi
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyoma Medical And Pharmaceuti
-
Basnet Purusotam
Research Center For Ethnomedicines Institute Of Natural Medicine Toyoma Medical And Pharmaceutical U
-
Basnet Purusotam
Research Center For Ethnomedicines Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
-
Nojima Hiroshi
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyoma Medical And Pharmaceuti
-
Tohda C
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
-
Tohda Chihiro
Research Center For Ethnomedicines Institute Of Natural Medicine Toyoma Medical And Pharmaceutical U
-
YASUDA Ikuyo
Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyoma Medical and Pharmaceu
-
KUMAGAI Noriko
Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyoma Medical and Pharmaceu
-
KOMATSU Kastuko
Research Center for Ethnomedicines, Institute of Natural Medicine, Toyoma Medical and Pharmaceutical
-
Yasuda Ikuyo
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyoma Medical And Pharmaceuti
-
Kumagai Noriko
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyoma Medical And Pharmaceuti
-
Komatsu Kastuko
Research Center For Ethnomedicines Institute Of Natural Medicine Toyoma Medical And Pharmaceutical U
-
Tohda Chihiro
Research Center For Ethnomedicine Institute Of Natural Medicine Toyama Medical And Pharmaceutical Un
-
Kuraishi Yasushi
Department Of Applied Pharmacology Faculty Of Pharmaceu Tical Sciences
-
Kuraishi Yasushi
Department Of Applide Biochemistry Research Institute For Wakan-yaku Toyama Toyama Medical And Pharm
関連論文
- Pharmacological Evaluation of Analgesic Effects of the Cholecystokinin2 Receptor Antagonist Z-360 in Mouse Models of Formalin- and Cancer-Induced Pain
- Involvement of Endothelin and ET_A Endothelin Receptor in Mechanical Allodynia in Mice Given Orthotopic Melanoma Inoculation
- A Mouse Model of Sural Nerve Injury-Induced Neuropathy : Gabapentin Inhibits Pain-Related Behaviors and the Hyperactivity of Wide-Dynamic Range Neurons in the Dorsal Horn
- Intracisternal, But Not Intrathecal, Injection of Naloxone Inhibits Cutaneous Itch-Related Response in Mice(Pharmacology)
- Five New C-Methyl Flavonoids, the Potent Aldose Reductase Inhibitors from Matteuccia orientalis TREV.
- THREE NOVEL DIARYLHEPTANOIDS, CALYXIN A, CALYXIN B, AND 3-EPI-CALYXIN B FROM A CHINESE CRUDE DRUG "YUNNAN CAO KOU" (ALPINIA BLEPHAROCALYX K. SCHUM.)
- MATTEUORIENATE A AND B, TWO NEW AND POTENT ALDOSE REDUCTASE INHIBITORS FROM MATTEUCCIA ORIENTALIS (HOOK.) TREV.
- DESENSITIZING NEUROMUSCULAR BLOCKADE BY p-PHENYLENE-POLYMETHYLENE BIS-AMMONIUM COMPOUNDS DEVELOPED FROM SUCCINYLCHOLINE
- Inhibitory Mechanisms of Glycoprotein Fraction Derived from Miscanthus sinensis for the Immediate Phase Response of an IgE-Mediated Cutaneous Reaction
- Evidence for Separate Involvement of Different μ-Opioid Receptor Subtypes in Itch and Analgesia Induced by Supraspinal Action of Opioids
- Pharmacological Evaluation of Morphine and Non-opioid Analgesic Adjuvants in a Mouse Model of Skin Cancer Pain(Pharmacology)
- Possible Involvement of 5-Lipoxygenase Metabolite in Itch-Associated Response of Mosquito Allergy in Mice
- Repeated Treatment With the Traditional Medicine Unsei-in Inhibits Substance P-Induced Itch-Associated Responses Through Downregulation of the Expression of Nitric Oxide Synthase 1 in Mice
- Inhibitory Effect of the Repeated Treatment with Unsei-in on Substance P-Induced Itch-Associated Responses through the Downregulation of the Expression of NK_1 Tachykinin Receptor in Mice
- Suppression by Gabapentin of Pain-Related Mechano-Responses in Mice Given Orthotopic Tumor Inoculation
- Inhibitory Effect of Azelastine on Allergic Itch-Associated Response in Mice Sensitized With Mosquito Salivary Glands Extract
- A Mouse Model of Sural Nerve Injury–Induced Neuropathy: Gabapentin Inhibits Pain-Related Behaviors and the Hyperactivity of Wide-Dynamic Range Neurons in the Dorsal Horn
- Mechanical Allodynia Induced by Paclitaxel, Oxaliplatin and Vincristine : Different Effectiveness of Gabapentin and Different Expression of Voltage-Dependent Calcium Channel α_2δ-1 Subunit(Pharmacology)
- Involvement of Tryptase and Proteinase-Activated Receptor-2 in Spontaneous Itch-Associated Response in Mice With Atopy-like Dermatitis
- Effects of Curcuma Drugs on Vasomotion in Isolated Rat Aorta(Pharmacognosy)
- Antipruritic Effects of the Supercritical Fluid Extract from Cnidii monnieri fructus (dried fruits of Cnidium monnieri CUSSON) in Mice
- Inhibitory Effects of Eleutherococcus senticosus Extracts on Amyloid β(25-35)-Induced Neuritic Atrophy and Synaptic Loss
- Dual effect of serotonin on formalin-induced nociception in the rat spinal cord
- Effects of the Prostaglandin E_1 Analog Limaprost on Mechanical Allodynia Caused by Chemotherapeutic Agents in Mice
- Activation of Proteinase-Activated Receptors Induces Itch-Associated Response Through Histamine-Dependent and -Independent Pathways in Mice
- Pharmacological Differences Between Static and Dynamic Allodynia in Mice With Herpetic or Postherpetic Pain
- Effects of Topical Application of Tacrolimus on Acute Itch-Associated Responses in Mice(Pharmacology)
- Effects of Loperamide on Mechanical Allodynia Induced by Herpes Simplex Virus Type-1 in Mice
- Roles of α-Adrenoceptors and Sympathetic Nerve in Acute Herpetic Pain Induced by Herpes Simplex Virus Inoculation in Mice
- Mechanical Hypersensitivity and Alterations in Cutaneous Nerve Fibers in a Mouse Model of Skin Cancer Pain
- Effects of Naltrexone on Spontaneous Itch-Associated Responses in NC Mice With Chronic Dermatitis
- Aconitine, a Main Component of Aconite, Increases Spontaneous Acetylcholine Release from the Frontal Cerebral Cortex of Freely Moving Rats
- ACETYLCHOLINE RECEPTOR-OPERATED INTRACELLULAR CALCIUM MOBILIZATION MODIFIED BY DIABETIC STATE IN SKELETAL MUSCLE
- HYPERSENSITIVITY OF ACETYLCHOLINE RECEPTOR IN DIABETIC SKELETAL MUSCLE TO NEUROMUSCULAR BLOCKERS : THE EFFECT ON MYOTUBES CULTURED WITH SPINAL CORD OR ITS EXTRACT
- Inhibitory Effect of Diarylheptanoids on Nitric Oxide Production in Activated Murine Macrophages
- Hepatoprotective Principles of Swertia japonica MAKINO on D-Galactosamine/Lipopolysaccharide-Induced Liver Injury in Mice
- Hepatoprotective Effect of Hovenia dulcis THUNB. on Experimental Liver Injuries Induced by Carbon Tetrachloride or D-Galactosamine : Lipopolysaccharide
- TETRAHYDROSWERTIANOLIN : A POTENT HEPATOPROTECTIVE AGENT FROM SWERTIA JAPONICA MAKINO
- Four Di-O-caffeoyl Quinic Acid Derivatives from Propolis. Potent Hepatoprotective Activity in Experimental Liver Injury Models
- POTENT ANTIHEPATOTOXIC ACTIVITY OF DICAFFEOYL QUINIC ACIDS FROM PROPOLIS
- Protective Effect of Celosian, an Acidic Polysaccharide, on Chemically and Immunologically Induced Liver Injuries
- Comparative Study of Seventeen Salvia Plants : Aldose Reductase Inhibitory Activity of Water and MeOH Extracts and Liquid Chromatography-Mass Spectrometry (LC-MS) Analysis of Water Extracts
- Constituents of Roots of Salvia deserta SCHANG. (Xinjiang-Danshen)
- Inhibitory Effect of Methanol Extract of Ganoderma lucidum on Acute Itch-Associated Responses in Mice
- Algogenic effects of Extract of the Tumor Mass Isolated from Mice with Orthotopic Melanoma Inoculation
- Roles of Mast Cells and Histamine in Mosquito Bite-Induced Allergic Itch-Associated Responses in Mice
- Caffeine inhibits paresthesia indced by herpes simlpex virus through action on primary sensory neurons in rats
- Itch-Associated Response Induced by Experimental Dry Skin in Mice
- Intradermal Cholinergic Agonists Induce Itch-Associated Response via M_3 Muscarinic Acetylcholine Receptors in Mice
- Characterization of itch-associated responses of NC mice with mite-induced chronic dermatitis
- Itch-Associated Responses of Afferent Nerve Innervating the Murine Skin: Different Effects of Histamine and Serotonin in ICR and ddY Mice
- Induction by carrageenan inflammation of prepronociceptin mRNA in VR1-immunoreactive neurons in rat dorsal root ganglia
- Pharmacological and Immunohistochemical Characterization of a Mouse Model of Acute Herpetic Pain
- RECS1 is a Negative Regulator of Matrix Metalloproteinase-9 Production and Aged RECS1 Knockout Mice are Prone to Aortic Dilation(EXPERIMENTAL INVESTIGATION)
- RECS1 deficiency in mice induces susceptibility to cystic medial degeneration
- Axonal and Dendritic Extension by Protopanaxadiol-Type Saponins From Ginseng Drugs in SK-N-SH Cells
- Scientific basis for the anti-dementia drugs of constituents from Ashwagandha (Withania somnifera)(Chemical & Pharmacological study)
- Withanolide Derivatives from the Roots of Withania somnifera and Their Neurite Outgrowth Activities
- Trigonelline-Induced Neurite Outgrowth in Human Neuroblastoma SK-N-SH Cells
- 2'-Hydroxymatteucinol, a New C-Methyl Flavanone Derivative from Matteccia orientalis; Potent Hypoglycemic Activity in Streptozotocin (STZ)-Induced Diabetic Rat
- Two New 2-Arylbenzofuran Derivatives from Hypoglycemic Activity-Bearing Fractions of Morus insignis
- Palbinone, a Novel Terpenoid from Peaonia albiflora; Potent Inhibitory Activity on 3α-Hydroxysteroid Dehydrogenase
- Structure, Expression and Chromosome Mapping of MLZE, a Novel Gene Which Is Preferentially Expressed in Metastatic Melanoma Cells
- Annexin VII as a Novel Marker for Invasive Phenotype of Malignant Melanoma
- Inhibitory Effects of the Methanol Extract of Ganoderma lucidum on Mosquito Allergy–Induced Itch-Associated Responses in Mice
- Tonic Inhibition of Allergic Itch Signaling by the Descending Noradrenergic System in Mice
- Isolation of Flat Revertants from Human Papillomavirus Type 18 E6E7 Transformed 3Y1 Cells by Transfection with a Rat Embryo Fibroblast cDNA Expression Library
- Effect of repeated cold stress on capsaicin-evoked release of glutamate from rat spinal dorsal horn slices
- A Large Scale Isolation of cDNAs Responsive to Shear Stress from Cultured Human Endothelial Cells
- Effects of the Prostaglandin E1 Analog Limaprost on Mechanical Allodynia Caused by Chemotherapeutic Agents in Mice
- Peripheral and Central Actions of Capsaicin and VR1 Receptor
- Antinociceptive Effects of Oriental Medicine Kei-Kyoh-Zoh-Soh-Oh-Shin-Bu-toh in Mice and Rats
- Aconitine Induces Bradycardia through a Transmission Pathway Including the Anterior Hypothalamus in Conscious Mice
- Serotonin-induced Biting of the Hind Paw is Itch-related Response in Mice
- Inhibitory Effects of Methanol Extracts of Herbal Medicines on Substance P-Induced Itch-Scratch Response
- Inhibition of Itch-Scratch Response by Fruits of Cnidium monnieri in Mice
- The Saccharomyces cerevisiae bud-neck proteins Kcc4 and Gin4 have distinct but partially-overlapping cellular functions
- Aodose Reductase Inhibitory Constituents of the Root of Salvia miltiorhiza BUNGE
- DANSHENOLS A AND B, NEW ALDOSE REDUCTASE INHIBITORS FROM THE ROOT OF SALVIA MILTIORHIZA BUNGE
- 28D-01 Propolis Prevents Diabetes and Increases Life Span in NOD Mice and Inhibits the STZ-Toxicity in Rats
- Analysis of Dissociated Single Neurons by Simple and Semi-Quantitative: RT-PCR (Reverse Transcription and Polymerase Chain Reaction)
- Blockade of Glycine Transporter (GlyT) 2, but Not GlyT1, Ameliorates Dynamic and Static Mechanical Allodynia in Mice With Herpetic or Postherpetic Pain
- Itch : Associated Response and Antinociception Induced by Intracisternal Endomorphins in Mice
- Itch-associated response induced by intradermal serotonin through 5-HT_2 receptors in mice
- Different Effects of Intrathecal Neurotoxins fot serotonergic and Catecholaminergic Systems on Antinociceptive Actions of Kei-Kyo-Zoh-Soh-Oh-Shin-Bu-toh and Morphine in Rats
- Involvement of Spinal Substance P and Excitatory Amino Acids in Inflammatory Hyperalgesia in Rats
- Antipruritic Effects of Sophora flavescens on Acute and Chronic Itch-Related Responses in Mice
- Acetylcholine-Induced Biphasic Effect on the Maximum Upstroke Velocity of Action Potential in Mouse Right Atria : Interaction With β-Adrenergic Signaling Cascade
- Endothelium-Dependent Potentiation of Prostaglandin F_Induced Contractions by (±)-[6]-Gingerol Is Inhibited by Cyclooxygenase- but Not Lipoxygenase-Inhibitors in Mouse Mesenteric Veins
- Blockade of Glycine Transporter (GlyT) 2, but Not GlyT1, Ameliorates Dynamic and Static Mechanical Allodynia in Mice With Herpetic or Postherpetic Pain
- Visualization of glutamate release from rat spinal cord with a confocal laser scanning microscope
- Intracisternal Injection of Opioids Induces Itch-Associated Response through μ-Opioid Receptors in Mice
- Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25-35)-induced neuritic atrophy in cultured rat cortical neurons
- A Comparative Study of Alkaloidal Constituents in Corydalis decumbens Tubers by High Performance Liquid Chromatography
- Diabetes mellitus-induced hypersensitivity of mouse skeletal muscles to acetylcholine and succinylcholine.
- Blocking effects of a new component, paeoniflorigenone, in paeony root on neuromuscular junctions of frogs and mice.
- Point Mutations in Phospholipase C-δ1 Gene of the Spontaneously Hypertensive Rat
- Depolarizing neuromuscular blocking action induced by electropharmacological coupling in the combined effect of paeoniflorin and glycyrrhizin.
- The External Ca2+-Dependence of Acetylcholine-Induced Contracture in Single Innervated and Denervated Skeletal Muscle Cells in Mice.
- Primary structure of the .ALPHA.-subunit of human Na,K-ATPase deduced from cDNA sequence.