Scientific basis for the anti-dementia drugs of constituents from Ashwagandha (Withania somnifera)(Chemical & Pharmacological study)

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概要

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• rights: 本文データは和漢医薬学会の許諾に基づきCiNiiから複製したものであるAlthough Ashwagandha (root of Withania somnifera) has been used for multi purposes but mainly as a tonic in the traditional Indian Ayurvedic medicine, this review focused on nootropic effects of Ashwagandha itself and isolated compounds from it. Several reports showed sitoindosides VII-X as active compounds for cognitive enhancer. However, our study revealed other active constituents, withanolide A, withanoside IV and withanoside VI, could improve Aβ(25-35) induced memory impairment, neuronal atrophy and synaptic loss in the cerebral cortex and the hippocampus. Treatment with Aβ(25-35) induced axonal and dendritic atrophy, and pre-synaptic and post-synaptic losses also in cultured rat cortical neurons. Subsequent treatment with withanolide A, withanoside IV and withanoside VI induced significant reconstruction of pre-synapses and post-synapses, in addition to regeneration of both axons and dendrites in the neurons. Withanolide A, withanoside IV and withanoside VI are therefore important candidates for the therapeutic treatment of neurodegenerative diseases, as it is able to reconstruct neuronal networks.Century COE program, Toyama Medical and Pharmaceutical University

• 和漢医薬学会の論文

著者

• TOHDA Chihiro

  Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical

• Komatsu Katsuko

  富山大学和漢医薬学総合研究所

• Komatsu K

  Institute Of Natural Medical Toyama Medicine And Pharmaceutical University

• Komatsu Katsuko

  Division Of Pharmacognosy Department Of Medicinal Resources Institute Of Natural Medicine Toyama Med

• Komatsu Katsuko

  Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu

• Komatsu Katsuko

  Division Of Pharmacognosy Institute Of Natural Medicine University Of Toyama

• KOMATSU Katsuko

  Century COE Program, Toyama Medical and Pharmaceutical University

• KUBOYAMA Tomoharu

  Century COE program, Toyama Medical and Pharmaceutical University

• Komatsu K

  Institute Of Natural Medicine University Of Toyama

• Komatsu Katsuko

  Division Of Pharmacognosy Department Of Medicinal Resources Istitute Of Natural Medicine University

• Tohda Chihiro

  富山大学和漢医薬学総合研究所 民族薬物研究センター 薬効解析部

• Tohda Chihiro

  Division Of Biofunctional Evaluation Research Center For Ethnomedicine University Of Toyama

• Tohda Chihiro

  Research Center For Ethnomedicine Institute Of Natural Medicine Toyama Medical And Pharmaceutical Un

• Kuboyama Tomoharu

  Division Of Pharmacognosy Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Komatsu Katsuko

  Division of Parmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama

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