Withanolide Derivatives from the Roots of Withania somnifera and Their Neurite Outgrowth Activities
スポンサーリンク
概要
- 論文の詳細を見る
Five new withanolide derivatives (1, 9-12) were isolated from the roots of Withania somnifera together with fourteen known compounds (2-8, 13-19). On the basis of spectroscopic and physiochemical evidence, compounds 1 and 9-12 were determined to be (20S,22R)-3α,6α-epoxy-4β,5β,27-trihydroxy-1-oxowitha-24-enolide (1), 27-O-β-D-glucopyranosylpubesenolide 3-O-β-D-glucopyranosyl (1→6)-β-D-glucopyranoside (withanoside VIII, 9), 27-O-β-D-glucopyranosyl (1→6)-β-D-glucopyranosylpubesenolide 3-O-β-D-glucopyranosyl (1→46)-β-D-glucopyranoside (withanoside IX, 10), 27-O-β-D-glucopyranosylpubesenolide 3-O-β-D-glucopyranoside (withanoside X, 11), and (20R,22R)-1α,3β,20,27-tetrahydroxywitha-5,24-dienolide 3-O-β-D-glucopyranoside (withanoside XI, 12). Of the isolated compounds, 1, withanolide A (2), (20S,22R)-4β,5β,6α,27-tetrahydroxy-1-oxowitha-2,24-dienolide (6), withanoside IV (14), withanoside VI (15) and coagulin Q (16) showed significant neurite outgrowth activity at a concentration of 1 μM on a human neuroblastoma SH-SY5Y cell line.
- 公益社団法人日本薬学会の論文
- 2002-06-01
著者
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ZHAO Jing
Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences of China Me
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花岡 美代次
金沢大学薬学部
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KOMATSU Katsuko
Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical
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ZHAO Jing
Institute of Natural Medicine, University of Toyama
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Nakamura N
Faculty Of Pharmaceutical Sciences Doshisha Women's College Of Liberal Arts
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TOHDA Chihiro
Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical
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Zhao J
Institute Of Natural Medicine University Of Toyama
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Zhao Jing
Department Of Hematology Peking Union Medical College Hospital
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Hattori Masao
Department Of Metabolic Engineering Institute Of Natural Medicine Toyama Medical And Pharmaceutical
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NAKAMURA Norio
Department of Metabolic Engineering, Institute of Natural Medicine, Toyama Medical and Pharmaceutica
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Nakamura N
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Komatsu Katsuko
富山大学和漢医薬学総合研究所
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Komatsu K
Div. Of Pharmacognosy Dep. Of Medicinal Resources Inst. Of Natural Medicine Univ. Of Toyama
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Komatsu K
Institute Of Natural Medical Toyama Medicine And Pharmaceutical University
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Komatsu Katsuko
Division Of Pharmacognosy Department Of Medicinal Resources Institute Of Natural Medicine Toyama Med
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Komatsu Katsuko
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Komatsu Katsuko
Research Center For Ethnomedicines Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
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Komatsu Katsuko
Division Of Pharmacognosy Institute Of Natural Medicine University Of Toyama
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KUBOYAMA Tomoharu
Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical
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Komatsu K
Institute Of Natural Medicine University Of Toyama
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Hattori Masao
Department Of Cell-resources Engineering Research Institute For Wakan-yaku (traditional Sino-japanes
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Komatsu Katsuko
Division Of Pharmacognosy Department Of Medicinal Resources Istitute Of Natural Medicine University
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Tohda Chihiro
富山大学和漢医薬学総合研究所 民族薬物研究センター 薬効解析部
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Tohda Chihiro
Division Of Biofunctional Evaluation Research Center For Ethnomedicine University Of Toyama
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Tohda Chihiro
Research Center For Ethnomedicine Institute Of Natural Medicine Toyama Medical And Pharmaceutical Un
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Nakamura Norio
Department Of Biology Yokohama City University
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Nakamura Norio
Department Of Anatomy Gunma University School Of Medicine
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Kuboyama Tomoharu
Division Of Pharmacognosy Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Zhao Jing
Department Of Chemical Environmental Engineering National University Of Singapore
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Zhao Jing
Department Of Cardiology Peking University First Hospital
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