Convenient Synthesis of 2,3,9,10-Tetraoxygenated Protoberberine Alkaloids and Their 13-Methyl Alkaloids
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概要
- 論文の詳細を見る
New and convenient synthesis of 2,3,9,10-tetraoxygenated protoberberine alkaloids and their 13-methyl alkaloids through the same intermediates was developed. Acylation of the brominated benzylphenethylamine (13) with α-chloro-α-(methylthio)acetyl chloride, followed by cyclization with stannic chloride, furnished tha key intermediates 4-methylthio-3-phenethylisoquinolin-3-ones (14), which were methylated to provide their methyl derivatives (17). Both isoquinolin-3-ones (14,17) were easily transformed into protoberberine alkaloids (16) and their 13-methyl alkaloids (21) in good yield.
- 社団法人日本薬学会の論文
- 2000-03-01
著者
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花岡 美代次
金沢大学薬学部
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HANAOKA Miyoji
Faculty of Pharmaceutical Sciences, Kanazawa University
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HIRASAWA Taeko
Faculty of Pharmaceutical Sciences, Kanazawa University
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CHO Won
Faculty of Pharmaceutical Sciences, Kanazawa University
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YASUDA Shingo
Faculty of Pharmaceutical Sciences, Kanazawa University
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Yasuda Shingo
Faculty Of Pharmaceutical Sciences Kanazawa University
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Hirasawa Taeko
Faculty Of Pharmaceutical Sciences Kanazawa University
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Hanaoka Miyoji
Faculty Of Pharmaceutical Sciences Kanazawa University
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Cho W
Faculty Of Pharmaceutical Sciences Kanazawa University
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Hattori Masao
Metabolic Engineering Institute Of Natural Medicine University Of Toyama
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花岡 美代次
Institute Of Natural Medicine University Of Toyama
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