鎮痙剤の研究(第4報)Diarylhydroxymethylquinolizidine Methohalidesの合成と抗アセチルコリン作用
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概要
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1-, 2-, and 3-Diarylhydroxymethylquinolizidine methohalides (4-8) were synthesized by quaternization of the corresponding tertiary amines (9-13) in order to develop new antispasmodics. Complete stereoselectivity was observed in the quaternization of the amines (9-13). The stereochemistry of these methohalides was confirmed by the chemical shift of N^+-methyl signals in the ^1H- and ^<13>C-nuclear magnetic resonance spectra. Some of these methohalides exhibited potent anticholinergic activities. Some structure-activity relationships are also discussed.
- 社団法人日本薬学会の論文
- 1980-01-25
著者
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加藤 日出男
北陸製薬株式会社
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小川 信男
北陸製薬株式会社中央研究所研究開発本部
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越中 栄一
Research and Development Division, Hokuriku Seiyaku Co., Ltd.,
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越中 栄一
Research And Development Division Hokuriku Seiyaku Co. Ltd.
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花岡 美代次
金沢大学薬学部
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