Quinolone系抗菌剤の研究(第3報)5-Amino-7-(2-aminoalkoxy)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid及びその関連化合物の合成と抗菌活性

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概要

• 論文の詳細を見る

• 5-Amino-7-(2-aminoalkoxy)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid and their derivatives (10,11) were prepared and their antibacterial activities were evaluated. As a result of in vitro antibacterial screening, the compounds having mono-or di-methyl (11d, e) group at α-position of amino group were most effective among the 7-aminoalkoxy derivatives. Structure-activity relationship of these compounds is also discussed.

• 社団法人日本薬学会の論文
• 1991-07-25

著者

• 加藤 日出男

  北陸製薬株式会社

• 安田 信吾

  北陸製薬株式会社中央研究所研究開発本部

• 伊藤 安夫

  Research and Development Division, Hokuriku Seiyaku Co., Ltd.,

• 伊藤 安夫

  北陸製薬株式会社研究開発本部

• 吉田 敏彦

  北陸製薬株式会社中央研究所

• 山本 陽一

  北陸製薬株式会社中央研究所

• 八木 典幸

  北陸製薬株式会社中央研究所

• 高橋 慶衛

  北陸製薬株式会社中央研究所

• 伊藤 安夫

  Research And Development Division Hokuriku Seiyaku Co. Ltd.

• 加藤 日出男

  北陸製薬株式会社中央研究所

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