(2-Pyrimidinylamino)phenylacetic Acid誘導体の合成と抗炎症作用

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概要

• 論文の詳細を見る

• A series of (2-pyrimidinylamino) phenylacetic acids was synthesized and tested for antiinflammatory activity and analgesic activity. These compounds were prepared by the condensation of anilines with 2-chloropyrimidines. Among them, 2-[3-fluoro-4-(2-pyrimidinylamino) phenyl] propionic acid (3i) showed potent anti-inflammatory activity. The structure-activity relationships are discussed.

• 社団法人日本薬学会の論文
• 1987-02-25

著者

• 加藤 日出男

  北陸製薬株式会社

• 小川 信男

  北陸製薬株式会社中央研究所研究開発本部

• 越中 栄一

  Research and Development Division, Hokuriku Seiyaku Co., Ltd.,

• 伊藤 安夫

  北陸製薬株式会社研究開発本部

• 吉田 敏彦

  北陸製薬株式会社中央研究所

• 牧野 栄一

  Central Research Laboratories, Hokuriku Seiyaku Co., Ltd.,

• 牧野 栄一

  北陸製薬株式会社 中央研究所

• 越中 栄一

  北陸製薬株式会社 中央研究所

• 越中 栄一

  Research And Development Division Hokuriku Seiyaku Co. Ltd.

• 伊藤 安夫

  Research And Development Division Hokuriku Seiyaku Co. Ltd.

• 牧野 栄一

  Central Research Laboratories Hokuriku Seiyaku Co. Ltd.

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