o-Chloro-α-(tert-butylaminomethyl)benzylalcohol Hydrochloride(C-78)および関連化合物の合成と気管支拡張作用

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概要

• 論文の詳細を見る

• For the development of a new bronchodilator, chloro-substituted α-(tert-butylamino-methyl) benzyl alcohols (VIIa-c) were synthesized via glyoxal derivatives. Further, hydroxy-substituted derivatives (VIII, IXa-e) of VIIa were synthesized by several methods. Among these compounds, o-chlorobenzyl alcohol hydrochloride (C-78) had a strong effect, and its 4-hydroxy derivative showed a strong effect, comparable to Salbutamol.

• 社団法人日本薬学会の論文
• 1978-09-25

著者

• 加藤 日出男

  北陸製薬株式会社

• 越中 栄一

  Research and Development Division, Hokuriku Seiyaku Co., Ltd.,

• 越中 栄一

  北陸製薬株式会社 中央研究所

• 越中 栄一

  Research And Development Division Hokuriku Seiyaku Co. Ltd.

• 久保 信治

  北陸製薬株式会社中央研究所

• 倉田 栄

  Research Laboratories, Hokuriku Seiyaku Co., Ltd.

• 倉田 栄

  北陸製薬株式会社中央研究所

• 山岸 輝里

  北陸製薬株式会社中央研究所

• 久保 信治

  北陸製薬 中研

• 倉田 栄

  Research Laboratories Hokuriku Seiyaku Co. Ltd.

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