Synthesis, Gastrointestinal Prokinetic Activity and Structure-Activity Relationships of Novel N-[[2-(Dialkylamino)ethoxy)benzyl]benzamide Derivatives

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概要

• 論文の詳細を見る

• Nobel N-[[2-(dialkylamino)ethoxy]benzyl]benzamide derivatives (II-1-51), derived form the structural modification of metoclopramide (i), were synthesized and examined for their pharmacological activities. Among them, N-[4-[2-(dimethylamino)ethoxy]benzyl]-3,4-dimethoxybenzamide (II-34) which exhibited well balanced gastrointestinal prokinetic and antiemetic activities was selected as a new type of gastrointestinal prokinetic agent.

• 社団法人日本薬学会の論文
• 1992-01-25

著者

• 加藤 日出男

  北陸製薬株式会社

• 岩永 裕氏

  北陸製薬株式会社

• 小川 信男

  北陸製薬株式会社中央研究所研究開発本部

• 安田 信吾

  北陸製薬株式会社中央研究所研究開発本部

• 坂口 順

  Research and Development Division, Hokuriku Seiyaku Co., Ltd.,

• 伊藤 安夫

  Research and Development Division, Hokuriku Seiyaku Co., Ltd.,

• 加藤 日出男

  Central Research Laboratories, Hokuriku Seiyaku Co., Ltd.,

• 伊藤 安夫

  Central Research Laboratories, Hokuriku Seiyaku Co., Ltd.,

• 安田 信吾

  Central Research Laboratory, Hokuriku Seiyaku Co., Ltd.,

• 坂口 順

  Central Research Laboratories, Hokuriku Seiyaku Co., Ltd.,

• 西野 博幸

  Central Research Laboratories, Hokuriku Seiyaku Co., Ltd.,

• 小川 信男

  Central Research Laboratories, Hokuriku Seiyaku Co., Ltd.,

• 岩永 裕氏

  Central Research Laboratories, Hokuriku Seiyaku Co., Ltd.,

• 坂口 順

  Research And Development Division Hokuriku Seiyaku Co. Ltd.

• 岩永 裕氏

  北陸製薬株式会社研究統括部薬理研究所

• 伊藤 安夫

  Research And Development Division Hokuriku Seiyaku Co. Ltd.

• 加藤 日出男

  北陸製薬株式会社中央研究所

• 西野 博幸

  Central Research Laboratories Hokuriku Seiyaku Co. Ltd.

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