1-Azabicyclo化合物の研究(第21報)1,2,3,10,11,11a-Hexahydro-5H-pyrrolo-[2,1-c][1,4]benzodiazepin-11-oneおよび5,6,6a, 7,8,9,10,12-Octahydropyrido[2,1-c][1,4]benzodiazepin-6-oneから中環状AminolactamおよびSpiroaminolactam体の合成

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概要

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• Reduction of the methiodides (VI and XV) with sodium amalgam gave the medium ring aminolactams (VII and XVI respectively) in an excellent yield. Treatment of VI and XV with phenyllithium resulted in the rearrangement to afford the spiroaminolactams (XI and XX), which were reduced with lithium aluminum hydride to the spirodiamines (XII and XXI, respectively). The spirodiamine (XII) was also obtained directly from VI on treatment with lithium aluminum hydride.

• 公益社団法人日本薬学会の論文
• 1974-12-25

著者

• 加藤 日出男

  北陸製薬株式会社

• 越中 栄一

  Research and Development Division, Hokuriku Seiyaku Co., Ltd.,

• 越中 栄一

  北陸製薬株式会社 中央研究所

• 荒田 義雄

  金沢大学薬学部

• 越中 栄一

  Research And Development Division Hokuriku Seiyaku Co. Ltd.

• 荒田 義雄

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 花岡 美代次

  金沢大学薬学部

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• 臭化チキジウム
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