Studies on 1-Azabicyclo Compounds. XXII. Stereochemistry of 9a-Substituted Quinolizidine Methiodides

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概要

• 論文の詳細を見る

• The stereochemistry of a number of the 9a-substituted quinolizidine methiodides was established, and confirmed from their ^<13>C-nuclear magnetic resonance (NMR) spectra. The N^+-methyl signals of the trans 9a-substituted quinolizidine methiodides were found to appear at lower field than those of the corresponding cis methiodides except for the 9a-cyano methiodides in their NMR spectra. On quaternization of the 9a-substituted quinolizidines with methyliodide, the formation of the cis methiodide vs. the corresponding trans methiodide increased according to the order of the bulkiness of the 9a-substituents as CH_2NO_2>CH_2OH>CH_2>CN>H.

• 社団法人日本薬学会の論文
• 1975-02-25

著者

• 荒田 義雄

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 花岡 美代次

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 花岡 美代次

  金沢大学薬学部

• 花岡 美代次

  Faculty Of Pharmaceutical Sciences Osaka University

• 花岡 美代次

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 亀井 道枝

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 青木 正

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 亀井 道枝

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 青木 正

  Faculty Of Pharmaceutical Sciences Kanazawa University

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