Synthesis of Pyrido[4,3-d]pyrimidin-5(6H)-ones via Anionic Cycloaddition of Methyl 2,4-Dimethoxy-6-methyl-5-pyrimidinecarboxylate with Imines

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概要

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• A new route is described for the synthesis of pyrido[4,3-d]pyrimidin-5(6H)-ones. Treatment of methl 2,4-dimethoxy-6-methyl-5-pyrimidinecarboxylate with lithium diisopropylamine in tetrahydrofuran at -70℃ under nitrogen followed by reaction with diaryl imines afforded cycloaddition products. The cycloadducts were aromatized to the corresponding pyrido[3,4-d]pyrimidin-5(6H)-ones by treatment with N-bromosuccinimide via a benzylic bromination-dehydrobromination sequence.

• 社団法人日本薬学会の論文
• 1991-05-25

著者

• 平井 秀一

  金沢大薬

• 和田 昭盛

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 花岡 美代次

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 花岡 美代次

  Faculty Of Pharmaceutical Sciences Osaka University

• 花岡 美代次

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 平井 秀一

  Faculty of Pharmaceutical Sciences, Kanazawa University

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