Sparsomycin Analogs.VI. : Synthesis and Antitumor Activity of Octylsparsomycin Analogs

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概要

• 論文の詳細を見る

• Five sparsomycin analogs (9-13) were prepared and examined for their ability to inhibit deoxyribonucleic acid (DNA) synthesis in L5178Y lymphoma cells. All of the compounds showed significant activity in the DNA synthesis assay. The compounds having R_C configuration exhibited almost the same activities independently of the configuration at the sulfoxide sulfur atom. Among the S_C isomers, the R_S configuration was advantageous for the appearance of activity.

• 社団法人日本薬学会の論文
• 1989-03-25

著者

• 田中 基裕

  Department of Experimental Therapeutics, Cancer Research Institute, Kanazawa University

• 佐々木 琢磨

  Department of Experimental Therapeutics, Cancer Research Institute, Kanazawa University

• 金友 昭一

  School of Pharmacy, Hokuriku University

• 永井 外夫

  School of Pharmacy, Hokuriku University

• 大木 一弘

  School of Pharmacy, Hokuriku University

• 長谷 哲子

  School of Pharmacy, Hokuriku University

• 大木 一弘

  北陸大学薬学部

• 金友 昭一

  北陸大学薬学部

• 金友 昭一

  School Of Pharmacy Hokuriku University

• 永井 外夫

  北陸大学薬学部

• 和田 昭盛

  School of Pharmacy, Hokuriku University

• 長谷 哲子

  School Of Pharmacy Hokuriku University

• 和田 昭盛

  Faculty Of Pharmaceutical Sciences Kanazawa University

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