Sparsomycin Analogs. III. Synthesis and Biological Activities of (E)-β-(6-Methyluracil-5-yl) acrylic Acid Derivatives
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概要
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In order to study the structure-activity relationship of sparsomycin, an antitumor antibiotic, 26 sparsomycin analogs (3-5) were synthesized and their antibacterial activities and lytic actions on Ehrlich ascites carcinoma cells were tested. It was found that N-[(E)-β-(6-methyluracil-5-yl) acryloyl]-S-methyl-D-cysteinol (5g) and N-[(E)-β-(6-methyluracil-5-yl) acryloyl]-D-methioninol (5i) showed significant antibacterial activity (minimum inhibitory concentration 25 μg/ml) against Streptococcus pyogenes.
- 社団法人日本薬学会の論文
- 1984-11-25
著者
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桶崎 英一
Research Laboratories Hokuriku Seiyaku Co. Ltd.
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桶崎 英一
Research And Development Division Hokuriku Seiyaku Co. Ltd.
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金友 昭一
School of Pharmacy, Hokuriku University
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永井 外夫
School of Pharmacy, Hokuriku University
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大木 一弘
School of Pharmacy, Hokuriku University
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長谷 哲子
School of Pharmacy, Hokuriku University
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野村 千秋
School of Pharmacy, Hokuriku University
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野村 千秋
School Of Pharmacy Hokuriku University
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大木 一弘
北陸大学薬学部
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金友 昭一
北陸大学薬学部
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金友 昭一
School Of Pharmacy Hokuriku University
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永井 外夫
北陸大学薬学部
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長谷 哲子
School Of Pharmacy Hokuriku University
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