The Structure of Viscosin, A Peptide Antibiotic. I. Syntheses of D-and L-3-Hydroxyacyl-L-leucine Hydrazides Related to Viscosin

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概要

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• Sixteen D-and L-3-hydroxyacyl-L-leucine hydrazides related to viscosin have been synthesized. Condensation of DL-3-hydroxy fatty acids with L-leucine methyl ester by the azide method or the active ester method gave DL-3-hydroxyacyl-L-leucine methyl esters, which were then converted to their hydrazides. Each of the racemic hydrazides could readily be resolved into the respective optically active diastereoisomers by means of fractional crystallization using alcohols. All of the D-and L-3-hydroxyacyl-L-leucine hydrazides prepared showed antimicrobial activity against four kinds of microorganisms only comparable to or less than that of the saturated straight chain fatty acids of corresponding carbon numbers.

• 公益社団法人日本薬学会の論文
• 1971-07-25

著者

• 平本 実

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 岡田 幸蔵

  近畿大学薬学部

• 岡田 幸蔵

  Faculty Of Pharmaceutical Science Kinki University

• 永井 外夫

  北陸大学薬学部

• 永井 外夫

  Faculty of Pharmaceutical Sciences, Hokuriku University

• 川本 寛

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 平本 実

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 川本 寛

  Faculty Of Pharmaceutical Sciences Kanazawa University

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