Application of Mass Spectrometry to Sequence Analysis of Pyroglutamyl Peptides from Snake Venoms : Contribution to the Confirmation of the Amino Acid Sequence of Bradykinin-potentiating Peptides B, C and E isolated from the Venom of Agkistrodon halys blom

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概要

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• The amino acid sequences of the three bradykinin-potentiating peptides from the venom of Agkistrodon halys blomhoffii (potentiators B, C, and E), which had been previously presented by Kato and Suzuki using conventional stepwise techniques, were smoothly confirmed by means of mass spectrometry coupled with enzymatic cleavage techniques. In the course of the sequencing, it was suggested that the preparation of potentiator B previously purified is contaminated by a small amount of the peptides with analogous amino acid sequences. The results showed the usefulness of mass spectrometric method in the sequence determination of naturally occurring peptides having N-terminal pyroglutamic acid and abundant proline residues. Mass spectrometric method was also effective for the detection of a small amount of contaminating peptide in the sample.

• 社団法人日本薬学会の論文
• 1973-10-25

著者

• 平本 実

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 鈴木 友二

  Institute for Protein Research, Osaka University

• 岡田 幸蔵

  近畿大学薬学部

• 平本 実

  Faculty Of Pharmaceutical Sciences Kanazawa University

関連論文

• Application of Mass Spectrometry to Sequence Analysis of Pyroglutamyl Peptides from Snake Venoms : Contribution to the Confirmation of the Amino Acid Sequence of Bradykinin-potentiating Peptides B, C and E isolated from the Venom of Agkistrodon halys blom
• Isolation of γ-L-Glutamyl-S-allylmercapto-L-cysteine and S-Allylmercapto-L-cysteine from Garlic
• Isolation of (-) S-Propenyl-L-cysteine from Garlic
• リノール酸の自動酸化におけるシステインおよびシステイン含有ジペプチド誘導体の抗酸化作用と抗酸化剤に対する相乗効果
• S-アルキルシステインおよびそのジペプチド誘導体の合成
• Synthesis and Antipepsin Activities of Peptides having a Valine or Valylvaline Moiety at the N-Terminus
• Mass Spectral Differentiation of α- and γ-Linkages in Glutamyl Oligopeptides and Its Application for Structure Elucidation of naturally Occurring Peptides
• N-Decanoyl-α一およびγ-Glutamyl Oligopeptide Methyl Ester類の合成
• Solid Phase Synthesis of Isariin, a Long Chain β-Hydroxy Acid-containing Cyclodepsipeptide, and Its Diastereoisomer
• パン酵母に対する陽イオン界面活性剤の増殖阻害について(第5報)陽イオン界面活性剤の抗菌作用機作
• Synthesis of Viscosic Acid
• パン酵母に対する陽イオン界面活性剤の増殖阻害について : (IV)対数増殖期の菌体に対する増殖阻害とビタミン類などの添加効果
• The Structure of Viscosin, A Peptide Antibiotic. II. Syntheses of D-and L-3-Hydroxyacylhexapeptides including the Proposed Structure of Viscosin and Its Optical Isomers
• The Structure of Viscosin, A Peptide Antibiotic. I. Syntheses of D-and L-3-Hydroxyacyl-L-leucine Hydrazides Related to Viscosin
• β-オキシ脂肪酸類のガスクロマトグラフィー

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