The Structure of Viscosin, A Peptide Antibiotic. II. Syntheses of D-and L-3-Hydroxyacylhexapeptides including the Proposed Structure of Viscosin and Its Optical Isomers

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概要

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• Homologs of D-and L-3-hydroxyacylhexapeptide including compound (I-1c) and its optical isomers (I-1'c, I-2c, I-2'c) were synthesized by condensing the tripeptide subunit with the dipeptide subunit followed by azide coupling of the resulting pentapeptide with D-or L-3-hydroxyacylleucine, and their antibacterial properties were examined. None of the synthetic acylhexapeptides was identical with viscosin in both physical and chemical properties and antituberculous activity.

• 公益社団法人日本薬学会の論文
• 1971-07-25

著者

• 平本 実

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 岡田 幸蔵

  近畿大学薬学部

• 岡田 幸蔵

  Faculty Of Pharmaceutical Science Kinki University

• 永井 外夫

  北陸大学薬学部

• 永井 外夫

  Faculty of Pharmaceutical Sciences, Hokuriku University

• 平本 実

  Faculty Of Pharmaceutical Sciences Kanazawa University

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