Sparsomycin Analogs. I. Synthesis of 5-Carboxy-6-methyluracil

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概要

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• Methods for the synthesis of 5-carboxy-6-methyluracil (9), which is expected to be useful as an intermediate for the preparation of sparsomycin analogs, were investigated. A new route that leads to 9 from cyanoacetylurea (5) via 2-cyano-3-oxobutanoylurea (6a), 5-cyano-6-methyluracil (7a), and 5-carbamoyl-6-methyluracil (8), was developed. The total yield from 5 to 9 was 20.7%.

• 社団法人日本薬学会の論文
• 1981-01-25

著者

• 金友 昭一

  School of Pharmacy, Hokuriku University

• 永井 外夫

  School of Pharmacy, Hokuriku University

• 長谷 哲子

  School of Pharmacy, Hokuriku University

• 金友 昭一

  北陸大学薬学部

• 金友 昭一

  School Of Pharmacy Hokuriku University

• 永井 外夫

  北陸大学薬学部

• 長谷 哲子

  School Of Pharmacy Hokuriku University

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