1,6-Dihydro-3 (2H)-pyridinones. V. Total Synthesis of (±)-Eburnamonine

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概要

• 論文の詳細を見る

• 3-Ethyl-3-methoxycarbonylmethylpiperidine (20) was prepared via the unsaturated aldehyde (12) derivel from benzyl 1,6-dihydro-3 (2H)-pyridinone-1-carboxylate (5b). N-Chlorination of 20 and subsequent exposure to a base afforded rel-(2S, 3R)-3-ethyl-2-hydroxypiperidine-3-acetic acid γ-lactone (3) in a good yield. According to the known method, the lactone (3) was converted into (±)-eburnamonine (1) and (±)-epieburnamonine (31). A possible pathway from 20 to 3 is also discussed.

• 公益社団法人日本薬学会の論文
• 1983-04-25

著者

• 今西 武

  Faculty Of Pharmaceutical Sciences Osaka University

• 井上 誠

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 中井 章

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 花岡 美代次

  Faculty Of Pharmaceutical Sciences Osaka University

• 花岡 美代次

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 宮下 賢一

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 宮下 賢一

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 井上 誠

  Faculty Of Pharmaceutical Sciences Kanazawa University

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