A FORMAL TOTAL SYNTHESIS OF (±)-QUADRONE

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概要

• 論文の詳細を見る

• This article deals with a formal total synthesis of (±)-quadrone (1), an antitumor sesquiterpene. The cyclopentenone (3) was trans-formed into cyclopropane derivative (2), a regioselective reductive ring opening of which and trapping of the enolate intermediate (16) by a C-1 unit afforded the diquinaneacetate (17). By a two-step sequence 17 was converted into methyl (1R^*, 5R^*, 6R^*)-6-(2-hydroxyethyl)-7,7-dimethyl-2-methylene-3-oxobicyclo [3. 3. 0] octane-1-acetate (19), which had already been proved to be an intermediate for (±)-1.

• 社団法人日本薬学会の論文
• 1985-01-25

著者

• 今西 武

  Faculty Of Pharmaceutical Sciences Osaka University

• 田中 徹明

  Faculty of Pharmaceutical Sciences, Osaka University

• 岩田 宙造

  Faculty of Pharmaceutical Sciences, Osaka University

• 鈴木 賢治

  Suntory Institute For Biomedical Research Wakayamadai

• 青木 昇一

  Faculty of Pharmaceutical Sciences, Osaka University

• 青木 昇一

  Toyobo Co. Ltd. Katata Research Institute

• 田中 徹明

  阪大院薬

• 田中 徹明

  Faculty Of Pharmaceutical Sciences Osaka University

• Tanaka T

  Kvushu Univ. Fukuoka Jpn

• 山下 正行

  Faculty of Pharmaceutical Sciences, Osaka University

• Tanaka T

  Osaka Univ. Osaka Jpn

• 鈴木 賢治

  Faculty of Pharmaceutical Sciences, Osaka University

• 岩田 宙造

  Faculty Of Pharmaceutical Sciences Osaka University

• 鈴木 賢治

  Faculty Of Pharmaceutical Sciences Osaka University

• 高橋 以都美

  Faculty Of Pharmaceutical Sciences Osaka University

• 荒川 治之

  Faculty of Pharmaceutical Sciences, Osaka University

• Imamura T

  Faculty Of Pharmaceutical Sciences Osaka University

• 山下 正行

  Faculty Of Pharmaceutical Sciences Osaka University

• 荒川 治之

  Faculty Of Pharmaceutical Sciences Osaka University

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