3-Hydroxypyrroles. I. A General Synthetic Route to 4,5-Unsubstituted Alkyl 3-Hydroxypyrrole-2-carboxylates

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概要

• 論文の詳細を見る

• The synthesis of 4,5-unsubstituted alkyl 3-hydroxypyrrole-2-carboxylates was described. An equimolar mixture of glycine esters (6) and diethyl ethoxymethylenemalonate (7) gave the condensation products (8) with liberation of ethanol. 3-Hydroxypyrrole-2,4-dicarboxylates (9) were obtained by the Dieckmann condensation of 8 using alkoxide as condensing agent. Selective partial hydrolysis of pyrrole-diesters (9) using a large excess of alkali hydroxide afforded the 4-carboxylic acids (10), which readily gave alkyl 3-hydroxypyrrole-2-carboxylates (5) on decarboxylation in boiling β-picoline or pyridineacetic acid in good yields.

• 公益社団法人日本薬学会の論文
• 1978-07-25

著者

• 山田 和代

  Faculty Of Pharmaceutical Sciences Osaka University

• 田中 徹明

  Faculty of Pharmaceutical Sciences, Osaka University

• 田中 徹明

  Faculty Of Pharmaceutical Sciences Osaka University

• 百瀬 雄章

  Faculty of Pharmaceutical Sciences, Kinki University

• 百瀬 雄章

  富山医薬大・薬

• 百瀬 雄章

  (present Address)faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 百瀬 雄章

  Faculty Of Pharmaceutical Sciences Osaka University

• 横田 卓士

  Faculty of Pharmaceutical Sciences, Osaka University

• 永本 典生

  Faculty of Pharmaceutical Sciences, Osaka University

• 横田 卓士

  Faculty Of Pharmaceutical Sciences Osaka University

• 百瀬 雄章

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 永本 典生

  Research Laboratories, Dainippon Pharmaceutical Co., Ltd.

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