Synthetic Studies on Anthracyclinones. XIV. On the Conformational Aspects of Ring A of Daunomycinone : A Model Study

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概要

• 論文の詳細を見る

• A pair of stereoisomers of the ring A model for daunomycinone was synthesized. The stereochemistries of isomeric α-tetralol-type intermediates and of the target compounds were discussed on the basis of spectral evidences. For all of the synthetic cis-1,3-glycol systems related to ring A of daunomycinone were demonstrated a favorable di-axial conformation of the hydroxyls and the outside orientation of the O-H bond in the quasi-axial benzylic hydroxyl, while a quasi-equatorial conformation of the benzylic hydroxyl was found favorable for trans-1,3-glycol system of the stereoisomers epimeric at C_1.

• 社団法人日本薬学会の論文
• 1976-07-25

著者

• 尾崎 裕

  Faculty Of Pharmaceutical Sciences Osaka University

• 百瀬 雄章

  Faculty of Pharmaceutical Sciences, Kinki University

• 百瀬 雄章

  (present Address)faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 百瀬 雄章

  Faculty Of Pharmaceutical Sciences Osaka University

• 百瀬 雄章

  Faculty Of Pharmaceutical Sciences Kanazawa University

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