Synthetic Studies on Anthracyclinones. VIII. Synthesis of 4-Bromo-6-ethyl-1-naphthol

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概要

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• A convenient synthesis of 6-ethyl-1-naphthol (I) and its conversion into 4-bromo-6-ethyl-1-naphthol (VI) are described. Chromium trioxide oxidation of 6-ethyltetralin gave predominantly 6-ethyl-1-tetralone (IX), which was dehydrogenated with palladized charcoal to I. Bromination of I afforded VI, a starting material in the synthesis of bisanhydrodaunomycinone (V). Structuers of VI and IX were confirmed by alternative syntheses as shown in Chart 3.

• 公益社団法人日本薬学会の論文
• 1968-12-25

著者

• 堀井 善一

  Faculty Of Pharmaceutical Sciences Josai University

• 山村 志郎

  Faculty of Pharmaceutical Sciences, Osaka University

• 伯水 英夫

  大阪大学薬学部

• 山村 志郎

  Research Laboratories, Tanabe Seiyaku Co., Ltd.

• 山村 志郎

  Research Laboratories Tanabe Seiyaku Co. Ltd.

• 西角 孝子

  Faculty Of Pharmaceutical Sciences Osaka University

• 百瀬 雄章

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 伯水 英夫

  Faculty of Pharmaceutical Sciences, Osaka University

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