Studies on the Structure Activity Relationship of Adrenergic β-Mimetic Benzylamine Derivatives. II. 1-Alkylamino-2-phenyl-1,2,3,4-tetrahydronaphthalenes
スポンサーリンク
概要
- 論文の詳細を見る
The synthesis and adrenergic activity of stereoisomeric 1-methylamino- and 1-isopropylamino-2-(3,4,5-trimethoxyphenyl)-5,6-dihydroxy-1,2,3,4-tetrahydronaphthalenes (IIa, b and IIIa, b), rigid structures related to the benzylamine derivatives (I), are presented. These compounds were found to possess direct β-stimulating activity both in the isolated tracheal and right atrial preparations of the guinea pigs. The structure-activity relationship in this series is described.
- 社団法人日本薬学会の論文
- 1976-12-25
著者
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斎藤 清一
Organic Chemistry Research Laboratory
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清本 昭夫
Research Laboratories, Tanabe Seiyaku, Co., Ltd.
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清本 昭夫
Research Laboratories Tanabe Seiyaku Co. Ltd.
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岩沢 義郎
Research Laboratories Tanabe Seiyaku Co. Ltd.
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斉藤 清一
Research Laboratories, Tanabe Seiyaku Co., Ltd.
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斉藤 清一
Organic Chemistry Research Laboratory Tanabe Seiyaku Co . Ltd.
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山村 志郎
Research Laboratories, Tanabe Seiyaku Co., Ltd.
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山村 志郎
Organic Chemical Research Laboratory and Pharmacological Research Laboratory, Tanabe Seiyaku Co., Lt
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岩沢 義郎
Organic Chemical Research Laboratory and Pharmacological Research Laboratory, Tanabe Seiyaku Co., Lt
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大橋 元明
Organic Chemical Research Laboratory and Pharmacological Research Laboratory, Tanabe Seiyaku Co., Lt
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清本 昭夫
Organic Chemical Research Laboratory and Pharmacological Research Laboratory, Tanabe Seiyaku Co., Lt
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山村 志郎
Research Laboratories Tanabe Seiyaku Co. Ltd.
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大橋 元明
Lead Optimization Research Laboratory Tanabe Seiyaku Co. Ltd.
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