合成医薬品の研究(第1報)不飽和カルボン酸アミドおよびニトリルのラクタム化反応

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概要

• 論文の詳細を見る

• Cyclization of unsaturated nitriles and amides to lactams was investigated. The unsaturated nitriles (Ia-c) or amides (Id-g) cyclized to the lactams (IIa-g) in a good yield by heating with polyphosphoric acid or conc. phosphoric acid. By application of this reaction, N-(4,4-diphenyl-3-butenoyl)glycines (III, VII, IX) gave 10b-phenyl-1,10b-dihydropyrrolo[2,1-α]isoquinoline-3,6(2H, 5H)-diones (IV, VIII, X). Similar treatment of 4'-chloro-4,4-diphenyl-3-butenanilide (XIII) afforded various cyclization products ; N-(p-chlorophenyl)-4-phenyl-1-naphthylamine (XIV), 7-chloro-5,5-diphenyl-4,5-dihydro-1H-1-benzazepin-2(3H)-one (XV), 1-(p-chlorophenyl)-5,5-diphenylpyrrolidin-2-one (XVI), 4-phenyl-1-naphthol (XVII), and γ, γ-diphenylbutyrolactone (XVIII).

• 社団法人日本薬学会の論文
• 1977-02-25

著者

• 斉藤 清一

  Research Laboratories, Tanabe Seiyaku Co., Ltd.

• 斉藤 清一

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co . Ltd.

• 山脇 泰彦

  田辺製薬株式会社有機化学研究所

• 渡辺 正夫

  田辺製薬株式会社有機化学研究所

• 山村 志郎

  田辺製薬株式会社有機化学研究所

• 斎藤 清一

  田辺製薬株式会社有機化学研究所

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