Studies on 1,2,3,4-Tetrahydroisoquinolines. III. Syntheses and β-Adrenoceptor Activities of Methyl Derivatives of Trimetoquinol

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概要

• 論文の詳細を見る

• Three methyl derivatives (S-2,S-3,and S-4) of trimetoquinol (TMQ), in which one or both of the ring positions ortho to a phenolic group are substituted by a methyl group, were synthesized and evaluated for bronchodilating activity. They were prepared by NaBH_3CN reduction of the Mannich bases (S-6,S-8,and S-23) via the quaternary salts in a one-pot procedure followed by catalytic reduction on 10% Pd-C. A comparison of the 5-methyl derivative (S-2) with TMQ revealed that the duration of bronchodilating effect of S-2 is considerably longer than that of TMQ on intraduodenal administration.

• 社団法人日本薬学会の論文
• 1981-10-25

著者

• 伊藤 信夫

  Research Laboratories Tanabe Seiyaku Co. Ltd.

• 池沢 一郎

  Research Laboratories Tanabe Seiyaku Co. Ltd.

• 山田 幸一郎

  Research Laboratories, Tanabe Seiyaku, Co., Ltd.

• 武田 幹男

  Research Laboratories, Tanabe Seiyaku, Co., Ltd.

• 清本 昭夫

  Research Laboratories, Tanabe Seiyaku, Co., Ltd.

• 岩隈 建男

  Research Laboratories, Tanabe Seiyaku, Co., Ltd.

• 清本 昭夫

  Research Laboratories Tanabe Seiyaku Co. Ltd.

• 山田 幸一郎

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 武田 幹男

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 武田 幹男

  田辺製薬株式会社有機化学研究所

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