Studies on Trimetoquinol. II. The Metabolic Fate of Trimetoquinol
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概要
- 論文の詳細を見る
Racemic Trimetoquinol [dl-1-(3,4,5-trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (I)] hydrochloride was administered to rabbits and rats by intravenous injection and the metabolites excreted into the 24 hr urine pools were investigated. Unchanged I and five metabolites, dl-1-(3,4,5-trimethoxybenzyl)-6-methoxy-7-hydroxy-1,2,3,4-tetrahydroisoquinoline (II), dl-1-(3,4,5-trimethoxybenzyl)-6-hydroxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline (III) and glucuronides of I, II and III were identified. Species differences between rabbit and rat were observed in the capacity of O-methylation and in the ratio of the two O-methylated isomers. In rabbits, a majority of administered I appeared as glucuronide of I, whereas glucuronide of III occupied the highest proportion in rats.
- 公益社団法人日本薬学会の論文
- 1971-04-25
著者
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長尾 拓
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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清本 昭夫
Research Laboratories, Tanabe Seiyaku, Co., Ltd.
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清本 昭夫
Research Laboratories Tanabe Seiyaku Co. Ltd.
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長尾 拓
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
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佐藤 千代子
田辺製薬株式会社生物研究所
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佐藤 千代子
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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河野 武郎
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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清本 昭夫
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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河野 武郎
Biological Research Laboratory Tanabe Seiyaku Co. Ltd.
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清本 昭夫
Biological Research Laboratory, Tanabe Seiyaku Co. Ltd.
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