Differential Effects of Selective β_1-Agonist Stimulation on Epi-and Endocardial Oxygen Tension in Anesthetized Dogs
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概要
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We investigated the effects of selective β_1 adrenoceptor stimulation on oxygen tension (pO_2) in the myocardium of anesthetized dogs. A β_1-selective full agonist, T-0509 (0.01-0.05μg/kg, i. v.), caused positive inotropic and chronotropic effects, and increased left circumflex blood flow, although it did not change arterial blood pressure. These effects were inhibited by bisoprolol (10μg/kg), but not by ICI 118551 (30μg/kg). Under control conditions, subepicardial pO_2 (pO_<2epi>) and subendocardial pO_2 (pO_<2endo>) were approximately 33 and 27 mmHg, respectively. T-0509 (0.05μg/kg) decreased pO_<2epi> in all cases, with a mean decrease of 2.6±0.5mmHg, and this was significantly inhibited by bisoprolol. T-0509 caused an increase (7 out of 10 dogs) or a slight decrease (3 out of 10) in the pO_<2endo>; the mean increment was 2.0±1.3mmHg (n=10). Isoproterenol (0.01-0.05μg/kg, i. v.) exerted positive inotropic and chronotropic effects that were sensitive to bisoprolol, and a hypotensive effect that was sensitive to ICI 118551. Isoproterenol caused an increase in blood flow that was sensitive to ICI 118551. Isoproterenol (0.05μg/kg) decreased pO_<2epi> in all cases, with a mean decrease of 2.7±0.5mmHg, which was significantly inhibited by bisoprolol. Isoproterenol caused an increase (5 out of 10) or a slight decrease (5 out of 10) in the pO_<2endo>; the mean increment was 1.1±1.2mmHg (n=10). These results suggest that, while coronary arteries dilate during selective stimulation of β_1-adrenoceptors or nonselective stimulation of β-adrenoceptors, the oxygen supply is insufflcient in pO_<2epi> due to a marked increase in oxygen demand. However, pO_<2endo> does not readily decrease under these conditions.
- 社団法人日本薬学会の論文
- 1995-07-15
著者
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長尾 拓
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
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長尾 拓
東京大学薬学部毒性薬理学教室
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山崎 純
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
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田上 廣幸
Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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田上 廣幸
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
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