Coronary Vasodilating Effect of Some Chromanone Derivatives
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概要
- 論文の詳細を見る
The effects of benzylidene chromanones and its related compounds on coronary and femoral blood flow were examined in anesthetized dogs. They exhibited vasodilating activity in both vascular beds, but less active than that of papaverine. Intravenous administration of 3-(4'-β-diethylaminoethoxy)-benzylidene chromanone HCl (CDY-902) caused an increase in coronary blood flow as well as a transient hypotension and persistent negative chronotropic action. No significant effect of CDY-902 on myocardial oxygen consumption of the dog in situ was observed. On oxygen uptake of the rat heart slices CDY-902 elicited a decrease similar to papaverine. As the results were compared with those of papaverine, GTN and dipyridamole, CDY-902 appears to have a direct and nonselective effects on coronary vascular bed.
- 公益社団法人日本薬学会の論文
- 1972-01-25
著者
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長尾 拓
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
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高木 敬次郎
Faculty of Pharmaceutical Sciences, University of Tokyo
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高木 敬次郎
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(present
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加藤 仁
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(present
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長尾 拓
Faculty of Pharmaceutical Sciences, University of Tokyo
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加藤 仁
Faculty of Pharmaceutical Sciences, University of Tokyo
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西尾 伸太郎
Faculty of Pharmaceutical Sciences, University of Tokyo
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西尾 伸太郎
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
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