EFFECTS OF DIMORPHOLAMINE ON BLOOD PRESSURE
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概要
- 論文の詳細を見る
Dimorpholamine in 1 to 4 mg/kg produced an epinephrine-like pressor effect in dogs anesthetized with pentobarbital, the response being reversed by pretreatment with an alpha adrenergic blocker. The pressor effect was often preceded by a transient hypotension with marked slowing of the heart beat which disappeared after bilateral vagotomy or administration of hexamethonium.<BR>The major part of the pressor effect disappeared following bilateral adrenalectomy, and was resistant to hexamethonium. The minor part seemed to be composed of direct vascular, cardiotonic and central actions.<BR>Dimorpholamine might be referred to as a catecholamine releaser and/or a non-nicotinic ganglion stimulant in a broad sense. This nature was evidenced in the experiments with dogs or cats, but not with rabbits or rats.
- 公益社団法人 日本薬理学会の論文
著者
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加藤 仁
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(present
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佐治 美昭
Department of Pharmacology, Faculty of Medicine, University of Tokyo
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佐久間 昭
Department of Pharmacology, Institute for Cardiovascular Diseases, School of Medicine, Tokyo Medical and Dental University
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加藤 仁
Department of Pharmacology, Faculty of Medicine, University of Tokyo
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佐久間 昭
Department of Pharmacology, Faculty of Medicine, University of Tokyo
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