A POTENT COMPETITIVE INHIBITOR OF 5-HYDROXY-TRYPTAMINE: 3-(2-BENZYLAMINOETHYL)-5-METHOXYINDOL HYDROCHLORIDE
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概要
- 論文の詳細を見る
During works on anti-5-hydroxytryptamine activity of tryptamine derivatives, 3-(2-benzylaminoethyl)-5-methoxyindol hydrochloride (S-8) of which a chemical structure is shown in Chart 1 has been found to be a potent competitive inhibitor of 5-hydroxytryptamine (HT) action on the fundus of the isolated rat stomach, the isolated guinea pig uterus and the isolated guinea pig taenia caecum (taenia coli). It has been also found that S-8 depresses a rise of blood pressure of the rat caused by HT.
- 社団法人 日本薬理学会の論文
著者
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高木 敬次郎
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(present
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高柳 一成
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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入倉 勉
Department of Chemical Pharmacology, Kyorin Chemical Laboratory
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西納 啓吾
Department of Chemical Pharmacology, Kyorin Chemical Laboratory
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伊藤 雅俊
Department of Chemical Pharmacology, Kyorin Chemical Laboratory
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大久保 秀夫
Department of Chemical Pharmacology, Kyorin Chemical Laboratory
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一関 紀子
Department of Chemical Pharmacology, Kyorin Chemical Laboratory
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高柳 一成
Department of chemical Pharmacdogy, Faculty of Pharmaceutical Sciences, University of Tokyo
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高木 敬次郎
Department of chemical Pharmacdogy, Faculty of Pharmaceutical Sciences, University of Tokyo
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