Effects of Epoxidation on the Actions of Normorphine, Norcodeine, N-Allylnormorphine (Nalorphine) and N-Allylnorcodeine on the Electrically Stimulated Guinea Pig Ileum

スポンサーリンク

概要

• 論文の詳細を見る

• The effects of epoxidation of normorphine, norcodeine, N-allylnormorphine (nalorphine) and N-allylnorcodeine on the twitch response of guinea pig ileum to electrical stimulation were studied. Normorphine, norcodeine and their epoxides are narcotic agonists, while nalorphine, N-allylnorcodeine and their epoxides are agonist-antagonists. The agonistic effects (via mu-receptor) of normorphine and norcodeine were not influenced by epoxidation of the 7,8-double bond. Epoxidation also little influenced the competitive antagonistic action (via mu-receptor) of nalorphine and N-allylnorcodeine against morphine. On the other hand, the agonistic action (via kappa-receptor) of nalorphine and N-allylnorcodeine was considerably decreased by epoxidation.

• 公益社団法人日本薬学会の論文
• 1985-04-25

著者

• 広部 雅昭

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 高柳 一成

  Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences

• 広部 雅昭

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 高柳 一成

  Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences

• 広部 雅昭

  Department of Bioorganic and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of

• 高柳 一成

  Department of chemical Pharmacdogy, Faculty of Pharmaceutical Sciences, University of Tokyo

関連論文

• BACTERIOSTATIC EFFECT OF 4,7-DICYANOBENZOFURAZAN DUE TO INACTIVATION OF 2,3-DIHYDROXYISOVALERATE DEHYDRATASE
• FORMATION OF SUPEROXIDE BY BENZOFURAZANS IN ESCHERICHIA COLI UNDER AEROBIC INCUBATION
• Toxicities of Dicyanobenzofurazans with Formation of Superoxide in Escherichia coli
• Degradation of 1,3-Diaryl-1-nitrosoureas in Aqueous Solutions and in Organic Solvents(Organic,Chemical)
• Studies on the Oxidation of 5H-N-Substituted Dibenz[b, f]azepines. III. : Oxidative Metabolism by Rat Liver Microsomes
• Studies on the Oxidation of N-Substituted-dibenz [b, f] azepines. II. Syntheses and Reactions of 5H-Dibenz [b, f] azepine 10,11-Oxides
• OXIDATION OF TERTIARY AMINES AND SULFIDES BY AN IRON (III) PORPHYRIN-O_2-Na_2S_2O_4 SYSTEM AS A MODEL OF CYTOCHROME P-450
• Oxidative Dealkylation of Tertiary Amines by Iron (III) Porphyrin-Iodosoxylene System as a Model of Cytochrome P-450
• Studies on the Oxidation of N-Substituted-dibenz [b, f] azepines I. Oxidation with m-Chloroperbenzoic Acid
• Synthesis and Analgesic Activity of Morphine-7,8-oxide and Heroin-7,8-oxide
• Codeine-7,8-oxide (4,5α-Epoxy-7β, 8β-epoxy-3-methoxy-17-methylmorphinan-6α-ol) : Identification as a Metabolite of Codeine
• Stereospecific Synthesis of Codeine 7,8-Oxide and Codeinone 7,8-Oxide
• INTER-INDIVIDUAL DIFFERENCES OF (+)-4-[4-(4-METHYLPHENYL)PHENYLMETHOXY-1-PIPERIDINYL]BUTYRIC ACID ((+)-MPPB) DISPOSITION IN RATS
• NEW METHOD OF DETECTING NITRIC OXIDE PRODUCTION
• Structure-Activity Relationship of 3- and 4-Acyloxy-1-(1,3-dioxolan-4-ylmethyl) piperidine Derivatives
• Clusters [Fe_4S_4(SR)_4]^ as Novel Catalysts in Organic Reductions
• Steric and Electronic Effects of Methyl Substitutents at the 2- and 6-Positions on N-Benzyl-1.4-dihydronicotinamide(Organic,Chemical)
• Novel Rearrangement of Pyrazole N-Imines with Acetic Anhydride
• Syntheses of Novel Antimicrobial Compounds : Pyrazolo [5,1-b] thiazole, Imidazo [1,2-b] pyrazole, and Thiazolo [3,2-b] dihydro-1,2-diazepine
• High-Performance Liquid Chromatography of Fullerence (C_) in Plasma Using Ultraviolet and Mass Spectrometric Detection
• pH Lowering in Liposomal Dispersiond Induced by Phospholipid Peroxidation
• Alkyl Chain Length Dependency in Hydrolysis of Liposomal Phosphatidylcholine by Dialkylphosphate
• Toxicity of Singlet Oxygen Generated Thermolytically in Escherichia coli
• Characteristic Coloration in Formation of N-1-Pyridinio Amidate and Enhancing Effect of Benzaldehydes
• A Novel Metabolite of 3,4-Methylenedioxyamphetamine (MDA) : Formation of 3-Methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline and Its Pharmacological Effect
• Oxygen Activation by Iron(III)-Porphyrin/NaBH_4/Me_4N・OH System as Cytochrome P-450 Model. Oxygenation of Olefin, N-Dealkylation of Tertiary Amine, Oxidation of Sulfide, and Oxidative Cleavage of Ether Bond
• COMPARISON OF THE REACTIVITIES OF [Fe_4S_4(SPh)_4]^ AND [Fe_2S_2(SPh)_4]^
• REVERSIBLE ELECTROCHEMICAL REDUCTION OF 1,6,6a-TRITHIA-3,4-DIAZA-PENTALENES TO THEIR ANION RADICALS WITH THE PRODUCTION OF SUPEROXIDE
• COOXIDATION OF ENONES DURING REACTION OF SUPEROXIDE WITH ACIDIC AROMATIC AMINES
• INCREASING 5-LIPOXYGENASE INHIBITORY ACTIVITIES BY OXIDATIVE CONVERSION OF O-METHOXYPHENOLS TO CATECHOLS USING A Cu^ - ASCORBIC ACID - O_2 SYSTEM
• The Crystal Structure of the Bromoacetylated Dimer-A synthesized by the Reaction of Acridine with Hydroxylamine-O-sulfonic Acid
• DESIGN AND SYNTHESIS OF SULFUR-CONTAINING MORPHINE AND AN OPIOID RECEPTOR PROBE
• Atropine-like Activities of 2-Substituted 5-Piperidinomethylfuran Derivatives
• Studies on Photochemical Reaction of Air Pollutants. X. Identification of Nitrophenols in Suspended Particulates
• Studies on Photochemical Reactions of Air Pollutants. IX. Formation of o-Nitrophenol and p-Nitrophenol by Reaction of Benzene Oxide with NO_2 in Air
• Studies on Photochemical Reactions of Air Pollutants. VIII. Photochemical Epoxidation of Olefins with NO_2 in a Solid-Gas Phase System
• Reaction of N-Aminopyridinium Derivatives. V. Syntheses of 1-(N-Methylacetamido) alkylpyridinium Salts and Their Reaction with Cyanide Ion.
• Reaction of N-Aminopyridinium Derivatives. II. The Reactions of 1-(N-Acylalkylamino) pyridinium Salt Derivatives with Cyanide Ion. : A New Synthesis of Primary Amines.
• Comparison of Singlet Oxygen Production Efficiency of C_ with Other Photosensitizers, Based on 1268nm Emission
• Application of Chemical P-450 Model Systems to Study Drug Metabolism. III. : Metabolism of 3-Isobutyryl-2-isopropylpyrazolo[1,5-α]pyridine
• FACILE PREPARATION OF UNSTABLE METABOLIC INTERMEDIATES : EPOXIDE(S) OF PYRAZOLO[1,5-a]PYRIDINE DERIVATIVES BY THE CYTOCHROME P-450 CHEMICAL MODEL
• OXYGEN ACTIVATION AND OLEFIN OXYGENATION BY IRON (III) PORPHYRIN AS A MODEL OF CYTOCHROME P-450
• Oxidation of Sulfides and Epoxidation of Olefins Caused by the Reaction of Pd-Peroxo or Co-Superoxo Complex with Carboxylic Acid Derivatives
• 3-Alkoxycarbonyl-2-oxazolones and Their Homopolymers as Highly Preservable Amino-Protecting Reagents. tert-Butoxycarbonylation and Benzyloxycarbonylation of Amino Groups
• Thermal Equilibrations of 1,11-Dioxa [11] paracyclophane Derivatives in Cholesteric Liquid Crystals
• Facile Desulfurization of Thiocarbonyl Groups to Carbonyls by Superoxide. A Model of Metabolic Reactions
• Disulfide Cleavage and Insulin Denaturation by Active Oxygen in the Copper(II)/Ascorbic Acid System
• Reaction of N-Aminopyridinium Derivatives. IV. Syntheses of N-Aminoquinolinium Salts and Their Reaction with Cyanide Ion
• o_2-cu^-ASCORBIC ACID : A NOVEL OXIDATION SYSTEM FOR THE HIGHLY SELECTIVE O-CEALKYLATION OF 2-ALKOXYPHENOLS
• Epoxidation of Olefins by Superoxide in the Presence of Acyl Halide
• Effects of Epoxidation on the Actions of Normorphine, Norcodeine, N-Allylnormorphine (Nalorphine) and N-Allylnorcodeine on the Electrically Stimulated Guinea Pig Ileum
• Facile Synthesis of 3-Methylbenzene Oxide and 1-Methylbenzene Oxide, and ^1H-NMR Data for Diels-Alder Adducts of Three Methylbenzene Oxides with 4-Phenyl-1,2,4-triazoline-3,5-dione
• EFFECT OF CALCIUM IONS AND PHOSPHOLIPIDS ON ANTIACETYLCHOLINE ACTION OF ACETONE AND PAPAVERINE
• ACTIONS OF DOPAMINE AND ITS DERIVATIVES ON THE TAENIA CAECUM AND TRACHEAL MUSCLE FROM THE GUINEA PIG AND THE VAS DEFERENS FROM THE RAT
• Chemicopharmacological Studies on Antispasmodic Action. XVIII. On the Antibarium Action of Papaverine-like Antispasmodics tested on Plexus-free Circular Muscle and Innervated Longitudinal Muscle.
• PHARMACOLOGICAL EXPERIMENTS WITH THE ISOLATED EXTRAOCULAR MUSCLE FROM RABBIT
• A POTENT COMPETITIVE INHIBITOR OF 5-HYDROXY-TRYPTAMINE: 3-(2-BENZYLAMINOETHYL)-5-METHOXYINDOL HYDROCHLORIDE
• THE EFFECTS OF CHOLINE AND ITS ANALOGUES ON THE OUTPUT OF ACETYLCHOLINE FROM THE ISOLATED ILEUM OF THE GUINEA PIG
• BETA-ADRENERGIC BLOCKER, 2-(2-HYDROXY-3-TERT-BUTYLAMINOPROPOXY) CHLOROBENZENE HYDROCHLORIDE (D-69-12)
• BETA-ADRENERGIC RECEPTORS IN VARIOUS ORGANS
• MODE OF ACTION OF PARTIAL AGONISTS ON THE TAENIA CAECUM OF THE GUINEA PIG AND DRUG-RECEPTOR THEORY
• Reaction of N-Aminopyridinium Derivatives. VI. Properties of s-Triazolo [1,5-α] pyridine Ring.
• Reaction of N-Aminopyridinium Derivatives. III. Synthesis of s-Triazolo [1,5-α]-pyridine Ring.
• Application of Chemical P450 Model Systems to Studies on Drug Metabolism. I. Phencyclidine : A Multi-functional Model Substrate
• Reaction of N-Aminopyridinium Salt with Cyanide Ion
• Reactivity of [Fe(SAr)_4]^ (n=1 or 2) : Synthetic Model Complexes for Iron-Sulfur Protein, Rubredoxin
• A New View on the Site of Action of Pilocarpine and Arecoline in the Isolated Guinea Pig Ileum.
• OXIDIZED RUBREDOXIN MODEL. NOVEL SYNTHESIS BY LIGAND-SUBSTITUTION WITH DISULFIDE
• SYNERGISM AND DRUG-RECEPTOR
• EFFECTS OF STRYCHNINE, DERIVATIVES OF PHENYL ACETATE AND CATECHOLAMINES ON CONTRACTION AND ACETYL CHOLINE OUTPUT FROM THE CHOLINERGIC NERVE ENDING OF GUINEA PIG ILEUM

もっと見る 閉じる

スポンサーリンク